CES1

羧酸酯酶1（CES1）是一種重要的酶類，在人體內(nèi)多種生理過程中發(fā)揮關(guān)鍵作用。它的全稱是羧酸酯酶1（Carboxylesterase 1），也被稱為肝羧酸酯酶1、酰基輔酶A:膽固醇酰基轉(zhuǎn)移酶、ACAT、腦羧酸酯酶hBr1等。CES1主要存在于肝臟和肺組織中，在腸道中的表達(dá)量幾乎為零。該酶負(fù)責(zé)水解多種內(nèi)源性物質(zhì)，如膽固醇酯和甘油三酯，從而參與脂質(zhì)代謝的平衡調(diào)節(jié)。此外，CES1還能代謝多種外源性物質(zhì)，包括可卡因、海洛因等異生素，以及咪達(dá)普利、奧司他韋、伊立替康等藥物，在肝臟藥物清除中發(fā)揮著重要作用。CES1的突變會導(dǎo)致羧酸酯酶1缺乏癥，影響藥物的代謝和清除，進而可能引發(fā)多種疾病。近年來，研究人員發(fā)現(xiàn)CES1在藥物研發(fā)中也具有重要意義，例如，它可以作為藥物靶點，用于設(shè)計新型藥物或前藥，以提高藥物的成藥性和安全性。此外，CES1的基因多態(tài)性也可能影響藥物的代謝和療效，因此在藥物研發(fā)和臨床應(yīng)用中需要加以考慮。

熱銷產(chǎn)品

Recombinant Human Liver carboxylesterase 1 (CES1) (Active) (CSB-MP005258HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its ability to hydrolyze p-nitrophenylacetate. The specific activity is >40000 pmol/min/μg.

The purity of CES1 was greater than 95% as determined by SEC-HPLC

Recombinant Human Adenosine deaminase CECR1 (CECR1), partial (CSB-EP878938HU1)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Human Adenosine deaminase CECR1(CECR1) ELISA kit (CSB-EL005187HU)

驗證數(shù)據(jù)

貨號：CSB-EL005187HU

規(guī)格：96T/48T

靈敏度：0.078 ng/mL

檢測范圍：0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CES1 Protein

CES1 ELISA Kit

CES1 Proteins

CES1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP878938HU CSB-EP878938HU CSB-BP878938HU CSB-MP878938HU CSB-EP878938HU-B	Recombinant Human Adenosine deaminase CECR1 (CECR1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP878938HU1	Recombinant Human Adenosine deaminase CECR1 (CECR1), partial	E.coli