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CELF1

CELF1,全稱為CUG結合蛋白1(CUG-binding protein 1),也被稱為Elav樣家族成員1(Elav-like family member 1)或NAB50等。該蛋白屬于RNA結合蛋白,能夠識別并結合特定的RNA序列,參與調控多種生物學過程。CELF1在多種組織中表達,包括肌肉、神經系統和免疫系統等。其異常表達或功能失調與多種疾病的發生和發展密切相關,如1型強直性肌營養不良、心肌肥大、白內障、2型糖尿病以及多種癌癥等。近年來,CELF1被視為疾病治療的潛在靶點,相關藥物研發也取得了進展。例如,南京大學徐強/吳興新團隊發現了能夠選擇性抑制CELF1的小分子化合物841,該化合物有望成為治療肝纖維化等CELF1相關疾病的候選藥物。CELF1的研究為理解疾病發生機制和開發新型治療方法提供了新的思路。

熱銷產品

CELF1 Recombinant Monoclonal Antibody (CSB-RA561537A0HU)

驗證數據

CSB-RA561537A0HU

Western Blot
Positive WB detected in: U-937 whole cell lysate(20μg),U-251MG whole cell lysate(20μg), SH-SY5Y whole cell lysate(20μg), A549 whole cell lysate(20μg),HepG2 whole cell lysate(20μg),NIH/3T3 whole cell lysate(20μg),Hela whole cell lysate(20μg)
All lanes: CELF 1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 52 kDa
Observed band size: 55 kDa
Exposure time:1min20s

CSB-RA561537A0HU

IHC image of CSB-RA561537A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA561537A0HU

IHC image of CSB-RA561537A0HU diluted at 1:100 and staining in paraffin-embedded human stomach tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA561537A0HU

Immunofluorescence staining of Hela cell with CSB-RA561537A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA561537A0HU

Overlay Peak curve showing Hela cells stained with CSB-RA561537A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

CELF1 Antibodies

CELF1 for Homo sapiens (Human)

CELF1 Proteins

CELF1 Proteins for Homo sapiens (Human)



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