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CDK5

CDK5,即細胞周期素依賴蛋白激酶5,別名TPKII。CDK5最早是從牛腦組織中分離和篩選得到的,與cdc2和cdk2同源性分別為58%和62%。CDK5是一種非典型的絲氨酸/蘇氨酸激酶,需要與其激活因子p35、p39或p25結合才具有激酶活性。這些激活因子與CDK5結合后,主要在細胞膜、細胞質和核周區域發揮作用。CDK5在多種生物學過程中發揮作用,包括神經細胞遷移、軸突導向、突觸發生與傳遞,以及細胞凋亡和細胞存活的調控。在阿爾茨海默病(AD)中,CDK5能夠磷酸化tau蛋白,導致其過度磷酸化。

熱銷產品

Recombinant Human Cyclin-dependent kinase 5 (CDK5) (CSB-EP005067HUe1)

驗證數據

CSB-EP005067HUe1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CDK5 Antibody (CSB-PA547925)

驗證數據

CSB-PA547925

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA547925(CDK5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA547925

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA547925(CDK5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA547925

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, NIH/3T3 cells, Primary antibody: CSB-PA547925(CDK5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

CDK5 Antibodies

CDK5 for Homo sapiens (Human)

CDK5 Proteins

CDK5 Proteins for Homo sapiens (Human)



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