CD58
CD58，也被稱為淋巴細(xì)胞功能相關(guān)抗原3（LFA-3），是一種廣泛表達(dá)于多種細(xì)胞表面的糖蛋白。它主要與T/NK細(xì)胞表面的CD2分子相互作用，在細(xì)胞粘附和識(shí)別中發(fā)揮關(guān)鍵作用。CD58蛋白的存在能夠促進(jìn)免疫細(xì)胞間的相互作用，增強(qiáng)免疫細(xì)胞對靶細(xì)胞的識(shí)別和殺傷能力。此外，CD58蛋白還參與調(diào)節(jié)抗病毒反應(yīng)、自身免疫性疾病中的炎癥反應(yīng)、移植的免疫排斥和腫瘤細(xì)胞的免疫逃避等生物學(xué)過程。在疾病方面，CD58蛋白與口腔白斑、陣發(fā)性夜間血紅蛋白尿癥、銀屑病關(guān)節(jié)炎等疾病的發(fā)生發(fā)展密切相關(guān)。針對CD58蛋白的藥物研發(fā)也在不斷推進(jìn)，例如開發(fā)針對CD2和CD58的靶向療法，以及利用CD58蛋白作為腫瘤免疫治療的靶點(diǎn)。
熱銷產(chǎn)品
CD58 Antibody (CSB-PA004946ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Lymphocyte function-associated antigen 3 antibody at 2μg/ml
Lane 1: Hela whole cell lysate
Lane 2: Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 29, 27, 28 kDa
Observed band size: 29 kDa
Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA004946ESR1HU at dilution of 1:100
CD58 Recombinant Monoclonal Antibody (CSB-RA166177A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Raji whole cell lysate, K562 whole cell lysate, Hela whole cell lysate
All lanes: CD58 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 29, 27, 26 kDa
Observed band size: 55-70 kDa
CD58 Antibodies
CD58 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004946GA01HU | CD58 Antibody | Human | ELISA,WB |
| CSB-PA004946ESR1HU | CD58 Antibody | Human | ELISA, WB, IHC |
| CSB-PA205850 | CD58 Antibody | Human | ELISA,WB |
| CSB-PA001472 | CD58 Antibody | Human | WB, ELISA |
| CSB-PA005227 | CD58 Antibody | Human | WB, ELISA |
| CSB-RA166177A0HU | CD58 Recombinant Monoclonal Antibody | Human | ELISA, WB |
CD58 Proteins
CD58 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004946HU1 CSB-EP004946HU1 CSB-BP004946HU1 CSB-MP004946HU1 CSB-EP004946HU1-B |
Recombinant Human Lymphocyte function-associated antigen 3 (CD58), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004946HU | Recombinant Human Lymphocyte function-associated antigen 3 (CD58) | in vitro E.coli expression system |
