CD46

CD46為一種單鏈跨膜糖蛋白，屬于補體活化調(diào)節(jié)蛋白因子家族。CD46在細胞表面分布很廣，大多數(shù)正常細胞上都有CD46表達，包括造血細胞系、成纖維細胞、表皮細胞、內(nèi)皮細胞及星狀膠質(zhì)細胞等，但不同類型的細胞上表達的數(shù)量有所不同。大量研究表明CD46可以調(diào)節(jié)T細胞免疫力，特別是能夠控制炎癥。多項研究已證明CD46與多種免疫炎性疾病相關(guān)，在多發(fā)性硬化疾病過程中，缺乏CD46會影響T細胞的增殖與分化，從而導致抗炎癥因子IL-10分泌減少。類風濕關(guān)節(jié)炎患者的關(guān)節(jié)液和外周血中中性粒細胞里CD46高表達。另外，CD46的表達在腫瘤逃逸、缺血再灌注中也有明顯變化。因此，CD46可抑制補體系統(tǒng)活化從而減輕免疫反應(yīng)以及通過調(diào)節(jié)T細胞從而影響抗炎因子的生成，最終影響炎性反應(yīng)。

Recombinant Human CD46 活性蛋白實驗驗證數(shù)據(jù)

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized CD46 at 2 μg/ml can bind Anti-CD46 rabbit monoclonal antibody, the EC₅₀ of human CD46 protein is 0.8333-1.054 ng/ml.

CD46 Antibody

CD46 Protein

CD46 ELISA Kit

CD46 Antibodies

CD46 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA004939GA01HU	CD46 Antibody	Human	ELISA,WB
CSB-PA004939EA01HU	CD46 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA004939EB01HU	CD46 Antibody, HRP conjugated	Human	ELISA
CSB-PA004939EC01HU	CD46 Antibody, FITC conjugated	Human
CSB-PA930156	CD46 Antibody	Human	ELISA,IHC
CSB-PA923298	CD46 Antibody	Human	ELISA,IHC
CSB-RA908548A0HU	CD46 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC

CD46 for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA004939LA01MO	Cd46 Antibody	Mouse	ELISA, WB, IHC

CD46 Proteins

CD46 Proteins for Cavia porcellus (Guinea pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004939GU CSB-BP004939GU CSB-MP004939GU CSB-EP004939GU-B	Recombinant Guinea pig Membrane cofactor protein (CD46), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP004939GU	Recombinant Cavia porcellus Membrane cofactor protein (CD46), partial	E.coli
CSB-CF004939GU	Recombinant Guinea pig Membrane cofactor protein (CD46)	in vitro E.coli expression system

CD46 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004939PI1 CSB-EP004939PI1 CSB-BP004939PI1 CSB-MP004939PI1 CSB-EP004939PI1-B	Recombinant Pig Membrane cofactor protein (CD46), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004939PI	Recombinant Pig Membrane cofactor protein (CD46)	in vitro E.coli expression system

CD46 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004939MO CSB-BP004939MO CSB-MP004939MO CSB-EP004939MO-B	Recombinant Mouse Membrane cofactor protein (Cd46), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP004939MO	Recombinant Mouse Membrane cofactor protein (Cd46), partial	E.coli
CSB-CF004939MO	Recombinant Mouse Membrane cofactor protein (Cd46)	in vitro E.coli expression system

CD46 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004939DSU1 CSB-EP004939DSU1 CSB-BP004939DSU1 CSB-MP004939DSU1 CSB-EP004939DSU1-B	Recombinant Chlorocebus aethiops Membrane cofactor protein (CD46), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004939DSU	Recombinant Chlorocebus aethiops Membrane cofactor protein (CD46)	in vitro E.coli expression system

CD46 Proteins for Saguinus mystax (Moustached tamarin)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004939SWA CSB-EP004939SWA CSB-BP004939SWA CSB-MP004939SWA CSB-EP004939SWA-B	Recombinant Saguinus mystax Membrane cofactor protein (CD46)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD46 Proteins for Saimiri sciureus (Common squirrel monkey)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004939SWD CSB-EP004939SWD CSB-BP004939SWD CSB-MP004939SWD CSB-EP004939SWD-B	Recombinant Saimiri sciureus Membrane cofactor protein (CD46)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD46 Proteins for Saguinus oedipus (Cotton-top tamarin)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004939SWB1 CSB-EP004939SWB1 CSB-BP004939SWB1 CSB-MP004939SWB1 CSB-EP004939SWB1-B	Recombinant Saguinus oedipus Membrane cofactor protein (CD46), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004939SWB	Recombinant Saguinus oedipus Membrane cofactor protein (CD46)	in vitro E.coli expression system

CD46 Proteins for Pongo abelii (Sumatran orangutan)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP735647PYX CSB-EP735647PYX CSB-BP735647PYX CSB-MP735647PYX CSB-EP735647PYX-B	Recombinant Pongo abelii Membrane cofactor protein (CD46), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD46 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP740933BO CSB-EP740933BO CSB-BP740933BO CSB-MP740933BO CSB-EP740933BO-B	Recombinant Bovine Membrane cofactor protein (CD46), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD46 Proteins for Callithrix jacchus (White-tufted-ear marmoset)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP808496CYL CSB-EP808496CYL CSB-BP808496CYL CSB-MP808496CYL CSB-EP808496CYL-B	Recombinant Callithrix jacchus Membrane cofactor protein (CD46), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD46 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-CF004939HU	Recombinant Human Membrane cofactor protein (CD46)	in vitro E.coli expression system
CSB-MP004939HU	Recombinant Human Membrane cofactor protein (CD46), partial (Active)	Mammalian cell
CSB-EP004939HU1	Recombinant Human Membrane cofactor protein (CD46), partial	E.coli
CSB-MP004939HUc7	Recombinant Human Membrane cofactor protein (CD46), partial	Mammalian cell
CSB-MP004939HU-B	Recombinant Human Membrane cofactor protein (CD46), partial, Biotinylated	Mammalian cell