CD3E
CD3E，即T細(xì)胞受體復(fù)合物的CD3ε亞基，它是一種在T細(xì)胞表面表達(dá)的糖蛋白，由CD3E基因編碼。CD3E是T細(xì)胞受體（TCR）信號(hào)傳導(dǎo)復(fù)合物的一部分，與TCRαβ或TCRγδ亞單位非共價(jià)結(jié)合。其作用機(jī)制是在T細(xì)胞受體識(shí)別并結(jié)合到主要組織相容性復(fù)合物（MHC）呈遞的抗原肽時(shí)，CD3E與其他CD3分子協(xié)同，傳遞激活信號(hào)，導(dǎo)致T細(xì)胞的激活。信號(hào)通路涉及酪氨酸激酶的激活，如ζ鏈相關(guān)蛋白激酶76（ZAP-70），進(jìn)而激活下游的多種信號(hào)分子，包括磷脂酰肌醇3激酶（PI3K）、蛋白激酶C（PKC）和絲裂原激活蛋白激酶（MAPK）。這些信號(hào)通路最終導(dǎo)致T細(xì)胞增殖、分化和效應(yīng)功能的發(fā)展。在生物學(xué)意義上，CD3E對(duì)T細(xì)胞介導(dǎo)的免疫應(yīng)答至關(guān)重要，它參與調(diào)節(jié)細(xì)胞毒性T細(xì)胞和輔助T細(xì)胞的激活，對(duì)清除病原體、抗腫瘤免疫以及自身免疫反應(yīng)的調(diào)控具有重要作用。CD3E的功能異常可能與某些免疫缺陷和自身免疫疾病相關(guān)。
熱銷(xiāo)產(chǎn)品
Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial (CSB-MP004931HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of CD3E was greater than 90% as determined by SEC-HPLC
CD3E Recombinant Monoclonal Antibody (CSB-RA004931MA1HU)
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 006 events was performed.
CD3E Antibodies
CD3E for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA10484A0Rb | CD3E Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA10484C0Rb | CD3E Antibody, FITC conjugated | Human | |
| CSB-PA004931GA01HU | CD3E Antibody | Human | ELISA,WB,IHC |
| CSB-PA949010 | CD3E Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA005833 | CD3E Antibody | Human | WB, ELISA |
| CSB-PA070244 | CD3E Antibody | Human | WB, IHC, ELISA |
| CSB-PA004931HA01HU | CD3E Antibody | Human | ELISA, IHC, IF |
| CSB-PA004931HB01HU | CD3E Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004931HC01HU | CD3E Antibody, FITC conjugated | Human | |
| CSB-PA004931HD01HU | CD3E Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA004931MA1HU | CD3E Recombinant Monoclonal Antibody | Human | ELISA, FC |
CD3E Proteins
CD3E Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP004931MO | Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial | Yeast |
| CSB-BP004931MO CSB-MP004931MO CSB-EP004931MO-B |
Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004931MO | Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial | E.coli |
| CSB-EP004931MOc7 | Recombinant Mouse T-cell surface glycoprotein CD3 epsilon chain (Cd3e), partial | E.coli |
CD3E Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP004931DO1 CSB-EP004931DO1 CSB-BP004931DO1 CSB-MP004931DO1 CSB-EP004931DO1-B |
Recombinant Dog T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004931DO | Recombinant Dog T-cell surface glycoprotein CD3 epsilon chain (CD3E) | in vitro E.coli expression system |
CD3E Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP004931SH1 CSB-EP004931SH1 CSB-BP004931SH1 CSB-MP004931SH1 CSB-EP004931SH1-B |
Recombinant Sheep T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004931SH | Recombinant Sheep T-cell surface glycoprotein CD3 epsilon chain (CD3E) | in vitro E.coli expression system |
CD3E Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP004931HU | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast |
| CSB-EP004931HU(A4) | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E) | E.coli |
| CSB-CF004931HU | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E) | in vitro E.coli expression system |
| CSB-EP004931HU | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | E.coli |
| CSB-BP004931HU CSB-EP004931HU-B |
Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP004931HU | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Mammalian cell |
CD3E Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP637748BO CSB-EP637748BO CSB-BP637748BO CSB-MP637748BO CSB-EP637748BO-B |
Recombinant Bovine T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3E Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP725239CA CSB-EP725239CA CSB-BP725239CA CSB-MP725239CA CSB-EP725239CA-B |
Recombinant Cat T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3E Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP801781PI CSB-BP801781PI CSB-MP801781PI CSB-EP801781PI-B |
Recombinant Pig T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3E Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP822100MOV CSB-EP822100MOV CSB-BP822100MOV CSB-EP822100MOV-B |
Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CD3E Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP822537CH CSB-EP822537CH CSB-BP822537CH CSB-MP822537CH CSB-EP822537CH-B |
Recombinant Chicken T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3E Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP890601RB CSB-EP890601RB CSB-BP890601RB CSB-MP890601RB CSB-EP890601RB-B |
Recombinant Rabbit T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
