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CD33

CD33又名氨基肽酶N（APN），是一種跨膜糖蛋白，屬于唾液酸結合免疫球蛋白樣凝集素的一員。CD33在交聯或者配體結合后激活，介導抑制信號，調節細胞內鈣動員、細胞粘附、白血病細胞凋亡、髓系細胞成熟和細胞因子的產生等等。CD33在90%以上的急性髓系白血病患者都有表達。在造血干細胞表面沒有表達，在成熟的粒細胞和其他組織也沒有表達，CD33作為髓系白血病治療的潛力靶點，一批企業相繼布局了CD33藥物的研發，輝瑞的靶向CD33的ADC藥物Mylotarg已獲批上市。除了ADC藥物外，靶向CD33的雙抗藥物和CAR-T細胞療法亦在如火如荼地研發中。

Recombinant Human CD33 活性蛋白實驗驗證數據

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC₅₀ of human CD33 protein is 4.289- 5.312 ng/ml.

CD33 Antibody

CD33 Protein

CD33 ELISA Kit

CD33 Antibodies

CD33 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA004925GA01HU	CD33 Antibody	Human	ELISA,WB,IHC,IF
CSB-PA004925ESR1HU	CD33 Antibody	Human	ELISA, WB, IHC
CSB-PA004925ESR2HU	CD33 Antibody	Human	ELISA, IHC
CSB-PA006175	CD33 Antibody	Human	WB, ELISA
CSB-PA070366	CD33 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA243594	CD33 Antibody	Human	ELISA,WB,IHC
CSB-PA004925LA01HU	CD33 Antibody	Human	ELISA, WB, IHC
CSB-PA004925LD01HU	CD33 Antibody, Biotin conjugated	Human	ELISA

CD33 Proteins

CD33 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP004925HU CSB-BP004925HU CSB-EP004925HU-B	Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-CF004925HU(A4)	Recombinant Human Myeloid cell surface antigen CD33 (CD33)	in vitro E.coli expression system
CSB-MP004925HU	Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active)	Mammalian cell

CD33 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP730931MO CSB-EP730931MO CSB-BP730931MO CSB-MP730931MO CSB-EP730931MO-B	Recombinant Mouse Myeloid cell surface antigen CD33 (Cd33), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli