CCR3
CCR3（C-C趨化因子受體3）是一種主要分布于嗜酸性粒細(xì)胞、嗜堿性粒細(xì)胞及Th2細(xì)胞的G蛋白偶聯(lián)受體，也被稱為CD193。該蛋白通過與Eotaxin等趨化因子結(jié)合，調(diào)控免疫細(xì)胞向炎癥部位遷移，尤其在過敏性疾病中扮演核心角色。研究發(fā)現(xiàn)，其在哮喘患者的呼吸道、過敏性鼻炎鼻黏膜及特應(yīng)性皮炎皮損部位異常活躍，與嗜酸性粒細(xì)胞浸潤直接相關(guān)。近年還發(fā)現(xiàn)某些實(shí)體瘤微環(huán)境中CCR3高表達(dá)，可能參與腫瘤免疫逃逸，例如結(jié)腸癌中CCR3信號可能促進(jìn)血管生成。
針對CCR3的藥物研發(fā)曾聚焦于小分子拮抗劑，如GSK766994等早期候選藥物在臨床試驗(yàn)中因療效不足或脫靶效應(yīng)未能突破。目前策略轉(zhuǎn)向聯(lián)合療法，例如將CCR3抑制劑與抗IgE抗體奧馬珠單抗聯(lián)用，或開發(fā)雙功能抗體同時(shí)阻斷CCR3與IL-5通路。2022年跨國藥企公布的臨床前數(shù)據(jù)顯示，新型變構(gòu)抑制劑可選擇性抑制嗜酸性粒細(xì)胞遷移而不影響其他免疫細(xì)胞，為減少副作用提供新方向。但該靶點(diǎn)成藥性挑戰(zhàn)仍存，需進(jìn)一步驗(yàn)證其在復(fù)雜炎癥網(wǎng)絡(luò)中的調(diào)控機(jī)制。
熱銷產(chǎn)品
CCR3 Antibody (CSB-PA004842LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Mouse liver tissue
All lanes: CCR3 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
predicted band size: 42, 44 kDa
observed band size: 42 kDa
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA004842LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA004842LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CCR3 Antibodies
CCR3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005330 | CCR3 Antibody | Human | WB, ELISA |
| CSB-PA262645 | CCR3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA793937 | CCR3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA004842LA01HU | CCR3 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA004842LB01HU | CCR3 Antibody, HRP conjugated | Human | ELISA |
CCR3 Proteins
CCR3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004842HU1 CSB-EP004842HU1 CSB-BP004842HU1 CSB-MP004842HU1 CSB-EP004842HU1-B |
Recombinant Human C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842HU | Recombinant Human C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
| CSB-CF004842HUl3 | Recombinant Human C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004842MO1 CSB-EP004842MO1 CSB-BP004842MO1 CSB-MP004842MO1 CSB-EP004842MO1-B |
Recombinant Mouse Probable C-C chemokine receptor type 3 (Ccr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842MO | Recombinant Mouse Probable C-C chemokine receptor type 3 (Ccr3) | in vitro E.coli expression system |
CCR3 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004842MOW1 CSB-EP004842MOW1 CSB-BP004842MOW1 CSB-MP004842MOW1 CSB-EP004842MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842MOW | Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004842RA1 CSB-EP004842RA1 CSB-BP004842RA1 CSB-MP004842RA1 CSB-EP004842RA1-B |
Recombinant Rat C-C chemokine receptor type 3 (Ccr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842RA | Recombinant Rat C-C chemokine receptor type 3 (Ccr3) | in vitro E.coli expression system |
CCR3 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004842DSU1 CSB-EP004842DSU1 CSB-BP004842DSU1 CSB-MP004842DSU1 CSB-EP004842DSU1-B |
Recombinant Chlorocebus aethiops C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004842DSU | Recombinant Chlorocebus aethiops C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP714527DO1 CSB-EP714527DO1 CSB-BP714527DO1 CSB-MP714527DO1 CSB-EP714527DO1-B |
Recombinant Dog C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF714527DO | Recombinant Dog C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP858985MOV1 CSB-EP858985MOV1 CSB-BP858985MOV1 CSB-MP858985MOV1 CSB-EP858985MOV1-B |
Recombinant Macaca fascicularis C-C chemokine receptor type 3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF858985MOV | Recombinant Macaca fascicularis C-C chemokine receptor type 3 (CCR3) | in vitro E.coli expression system |
CCR3 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP878633DOA CSB-EP878633DOA CSB-BP878633DOA CSB-MP878633DOA CSB-EP878633DOA-B |
Recombinant Arabidopsis thaliana Putative serine/threonine-protein kinase-like protein CCR3 (CCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
