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CASZ1

CASZ1,全稱為castor zinc finger 1,是一種鋅指轉錄因子,也被稱為Cst、D4Ertd432e、2410019P08Rik等。它在聽覺毛細胞的命運穩定和生存維持中發揮重要作用。CASZ1在胚胎晚期至成年內毛細胞中持續高表達,而在胚胎晚期和幼年期外毛細胞中僅瞬時表達。研究顯示,CASZ1在維持內毛細胞命運和防止其轉變為外毛細胞中扮演關鍵角色,同時也在維持外毛細胞存活中發揮作用。此外,CASZ1的異常與多種疾病相關,如靜脈曲張、卵巢癌和T細胞急性淋巴細胞性白血病等。目前,針對CASZ1的研究正在推動相關藥物的研發,為治療這些疾病提供了新的思路。

熱銷產品

CASZ1 Antibody (CSB-PA773036LA01HU)

驗證數據

CSB-PA773036LA01HU

Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: CASZ1 antibody at 4.8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 191, 125 kDa
Observed band size: 191 kDa

CSB-PA773036LA01HU

IHC image of CSB-PA773036LA01HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CASZ1 Antibodies

CASZ1 for Homo sapiens (Human)

CASZ1 Proteins

CASZ1 Proteins for Homo sapiens (Human)