CAGE1
CAGE1，全稱為癌睪抗原1，常見別名有CTAG1B、CT1等。它在正常人體中僅主要于睪丸生殖細胞表達，卻在黑色素瘤、非小細胞肺癌、乳腺癌等多種惡性腫瘤里異常高表達。這種獨特的表達特征讓它成為腫瘤免疫治療的潛力靶點——腫瘤細胞表面的該蛋白可被免疫系統捕捉，啟動對腫瘤的攻擊反應。
CAGE1高表達常和腫瘤惡性程度、轉移傾向及患者差預后掛鉤，比如黑色素瘤患者中該蛋白陽性率較高，且陽性者復發和死亡風險更顯著。目前針對它的治療研究多聚焦免疫領域：基于其抗原肽的腫瘤疫苗已進入早期臨床，部分能誘導患者產生特異性T細胞，抑制腫瘤生長；靶向該蛋白的CAR-T療法也在實驗室研究中見成效，未來或為晚期實體瘤患者帶來新希望。
熱銷產品
Recombinant Human Cancer-associated gene 1 protein (CAGE1) (CSB-BP837427HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數據
Western blot analysis of extracts from HT-29 cells and Jurkat cells, using CAGE1 antibody.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using CAGE1 antibody.
CAGE1 Antibodies
CAGE1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA055054 | CAGE1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA001167 | CAGE1 Antibody | Human | WB, IHC, ELISA |
| CSB-PA442042 | CAGE1 Antibody | Human | ELISA,IHC |
| CSB-PA828264 | CAGE1 Antibody | Human | ELISA,IHC |
CAGE1 Proteins
CAGE1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP837427HU CSB-EP837427HU CSB-MP837427HU CSB-EP837427HU-B |
Recombinant Human Cancer-associated gene 1 protein (CAGE1) | Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP837427HU | Recombinant Human Cancer-associated gene 1 protein (CAGE1) | Baculovirus |
