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Your Good Partner in Biology Research

BCAM

BCAM蛋白全稱為基底細胞黏附分子,也被稱為Lutheran血型抗原或CD239,是一種跨膜糖蛋白。該蛋白主要表達于紅細胞、上皮細胞及多種腫瘤細胞表面,通過與細胞外基質中的層粘連蛋白結合參與細胞黏附及遷移過程。研究發現BCAM在鐮狀細胞病中異常活躍,其與血管內皮細胞的相互作用加劇了紅細胞的滯留,導致血管阻塞危象的發生。在惡性腫瘤領域,BCAM的高表達與卵巢癌、胰腺癌的轉移密切相關,可能通過激活特定激酶促進腫瘤細胞侵襲。近年來針對BCAM的靶向治療逐漸受到關注,已有研究團隊開發出阻斷BCAM與層粘連蛋白結合的單克隆抗體,在動物模型中顯示出抑制腫瘤轉移的效果。2022年一項針對鐮狀細胞病的II期臨床試驗中,BCAM抑制劑聯合抗凝血療法使患者疼痛危象發生率降低40%,目前該靶點的雙功能抗體藥物已進入臨床前評估階段。

熱銷產品

BCAM Antibody (CSB-PA341920LA01HU)

驗證數據

CSB-PA341920LA01HU

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA341920LA01HU at dilution of 1:100

CSB-PA341920LA01HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA341920LA01HU at dilution of 1:100

CSB-PA341920LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA341920LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

BCAM Antibodies

BCAM for Homo sapiens (Human)

BCAM Proteins

BCAM Proteins for Homo sapiens (Human)