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BAP1

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor.

BAP1 Antibodies

BAP1 for Homo sapiens (Human)

BAP1 Proteins

BAP1 Proteins for Bos taurus (Bovine)

BAP1 Proteins for Rattus norvegicus (Rat)

BAP1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

BAP1 Proteins for Branchiostoma floridae (Florida lancelet) (Amphioxus)

BAP1 Proteins for Gallus gallus (Chicken)

BAP1 Proteins for Xenopus laevis (African clawed frog)

BAP1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

BAP1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

BAP1 Proteins for Homo sapiens (Human)

BAP1 Proteins for Mus musculus (Mouse)



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