ASPN
ASPN 蛋白全稱為天冬氨酸富含亮氨酸重復蛋白（Asporin），常見別名包括 PLAP?1、PLAP1、OS3、SLRR1C，屬于細胞外基質中小亮氨酸富集蛋白聚糖家族成員。它主要分布于軟骨、牙周膜與結締組織，可結合膠原蛋白與鈣離子，參與基質礦化與組織穩態維持，同時調控軟骨發育與牙周韌帶分化，避免異常骨化。
ASPN 異常與骨關節炎、椎間盤退變密切相關，其多態性會提升關節病變風險，也在胃癌等腫瘤中異常升高，影響細胞增殖與侵襲。目前該蛋白多用于骨關節疾病風險評估與腫瘤輔助診斷，針對其調控網絡的小分子干預、基因編輯等策略正處于臨床前研究階段，為退行性關節病與實體瘤提供潛在干預方向。
熱銷產品
Recombinant Human Asporin (ASPN) (CSB-EP002230HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ASPN Antibody (CSB-PA002230LA01HU)
驗證數據
Western blot
All lanes: ASPN antibody at 14 μg/ml
Lane 1: Mouse heart tissue
Lane 2: Mouse liver tissue
Lane 3: HL60 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 43 kDa
Observed band size: 43 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA002230LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA002230LA01HU at dilution of 1:100
Human Asporin(ASPN) ELISA kit (CSB-EL002230HU)
驗證數據
貨號：CSB-EL002230HU
規格：96T/48T
靈敏度：8.59 pg/mL
檢測范圍：34.37 pg/mL-2200 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ASPN Antibodies
ASPN for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA293991 | ASPN Antibody | Human,Mouse | ELISA,WB |
| CSB-PA002230LA01HU | ASPN Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA002230LC01HU | ASPN Antibody, FITC conjugated | Human |
ASPN Proteins
ASPN Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP002230HU CSB-BP002230HU CSB-MP002230HU CSB-EP002230HU-B |
Recombinant Human Asporin (ASPN) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002230HU | Recombinant Human Asporin (ASPN) | E.coli |
ASPN ELISA Kit
ASPN ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL002230HU | Human Asporin(ASPN) ELISA kit | serum, plasma, tissue homogenates | 8.59 pg/mL |
