AREG

AREG（Amphiregulin），全稱(chēng)雙向調(diào)節(jié)素，也被稱(chēng)為雙調(diào)蛋白或表皮生長(zhǎng)因子受體配體，是表皮生長(zhǎng)因子家族的重要成員。AREG通過(guò)與細(xì)胞表面的EGFR蛋白結(jié)合，激活下游信號(hào)網(wǎng)絡(luò)，參與調(diào)控細(xì)胞增殖、分化及組織修復(fù)過(guò)程。研究發(fā)現(xiàn)，AREG在多種惡性腫瘤中異常活躍，例如結(jié)直腸癌、非小細(xì)胞肺癌和三陰性乳腺癌，其過(guò)表達(dá)會(huì)加速腫瘤生長(zhǎng)、轉(zhuǎn)移及化療耐藥。AREG蛋白在哮喘、特應(yīng)性皮炎等慢性炎癥疾病中可增強(qiáng)免疫細(xì)胞活性，并與特發(fā)性肺纖維化的異常成纖維細(xì)胞活化密切相關(guān)。目前針對(duì)AREG相關(guān)通路的治療藥物以EGFR靶向藥為主，如西妥昔單抗、帕尼單抗等已用于臨床，但直接抑制AREGF的藥物研發(fā)仍處于早期階段。近年來(lái)，聯(lián)合靶向AREG與免疫檢查點(diǎn)的療法在動(dòng)物模型中顯示出協(xié)同抗腫瘤效果，為克服EGFR抑制劑耐藥提供了新方向。

熱銷(xiāo)產(chǎn)品

AREG Antibody (CSB-PA11339A0Rb)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA11339A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA11339A0Rb at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA11339A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

AREG Antibody

AREG Protein

AREG ELISA Kit

AREG Antibodies

AREG for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA001986GA01HU	AREG Antibody	Human	ELISA,WB,IHC,IF
CSB-PA006314	AREG Antibody	Human	WB, ELISA
CSB-PA441346	AREG Antibody	Human	ELISA,WB
CSB-PA694774	AREG Antibody	Human	ELISA,WB
CSB-PA11339A0Rb	AREG Antibody	Human	ELISA, IHC, IF
CSB-PA11339B0Rb	AREG Antibody, HRP conjugated	Human	ELISA
CSB-PA11339C0Rb	AREG Antibody, FITC conjugated	Human
CSB-PA11339D0Rb	AREG Antibody, Biotin conjugated	Human	ELISA

AREG Proteins

AREG Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP001986HU1 CSB-EP001986HU1 CSB-BP001986HU1 CSB-MP001986HU1 CSB-EP001986HU1-B	Recombinant Human Amphiregulin (AREG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP002641HU	Recombinant Human Amphiregulin protein (AREG), partial (Active)	E.Coli
CSB-CF001986HU	Recombinant Human Amphiregulin (AREG)	in vitro E.coli expression system

AREG Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP001986MO1 CSB-EP001986MO1 CSB-BP001986MO1 CSB-MP001986MO1 CSB-EP001986MO1-B	Recombinant Mouse Amphiregulin (Areg), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF001986MO	Recombinant Mouse Amphiregulin (Areg)	in vitro E.coli expression system

AREG Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP001986RA1 CSB-EP001986RA1 CSB-BP001986RA1 CSB-MP001986RA1 CSB-EP001986RA1-B	Recombinant Rat Amphiregulin (Areg), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF001986RA	Recombinant Rat Amphiregulin (Areg)	in vitro E.coli expression system