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APRIL

APRIL,即增殖誘導(dǎo)配體,別名CD256、TNFSF13。它是一種主要由髓系細胞產(chǎn)生的蛋白質(zhì),包括常規(guī)樹突狀細胞、濾泡DC、單核細胞、中性粒細胞和巨噬細胞,活化的B細胞也少量產(chǎn)生APRIL。APRIL的作用機制涉及與其受體TACI、BCMA和HSPG的結(jié)合,通過這些相互作用參與調(diào)節(jié)B細胞的激活、漿細胞的存活以及免疫球蛋白的同種型轉(zhuǎn)換。APRIL在多種生理過程中發(fā)揮作用,包括B細胞的成熟、抗體的類別轉(zhuǎn)換以及長壽命漿細胞的形成。此外,APRIL在多種疾病中也有重要作用,包括自身免疫性疾病如系統(tǒng)性紅斑狼瘡(SLE)和IgA腎病(IgAN),以及多種類型的癌癥,如乳腺癌、結(jié)直腸癌和非小細胞肺癌等。APRIL的異常表達與腫瘤細胞的增殖、存活和侵襲有關(guān),使其成為潛在的治療靶點。

熱銷產(chǎn)品

TNFSF13 Antibody (CSB-PA023989ESR1HU)

驗證數(shù)據(jù)

CSB-PA023989ESR1HU

Western blot
All lanes: Tumor necrosis factor ligand superfamily member 13 antibody at 10μg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 28, 26, 25, 37, 23 kDa
Observed band size: 28 kDa

CSB-PA023989ESR1HU

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA023989ESR1HU at dilution of 1:100

CSB-PA023989ESR1HU

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA023989ESR1HU at dilution of 1:100

Human a proliferation inducing ligand(APRIL)ELISA Kit (CSB-E15012h)

驗證數(shù)據(jù)

CSB-E15012h 標(biāo)準(zhǔn)曲線

貨號:CSB-E15012h

規(guī)格:96T/48T

靈敏度:0.195 ng/mL

檢測范圍:0.78 ng/mL-50 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

APRIL Antibodies

APRIL for Homo sapiens (Human)

APRIL Proteins

APRIL Proteins for Homo sapiens (Human)

APRIL ELISA Kit

APRIL ELISA Kit for Homo sapiens (Human)