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APP

APP(Amyloid Precursor Protein)的主要功能是參與神經細胞的生長、發育和修復,并影響突觸形成和可塑性。他的結構包括一個N端信號肽、大約660個氨基酸組成的外顯區域,以及一個C端跨膜區和胞內區域。在正常情況下,APP會通過非淀粉樣途徑被酶解,產生具有生理功能的代謝產物。然而,異常的代謝途徑可能導致β-淀粉樣蛋白(β-amyloid)的積聚,這是阿爾茨海默病的主要病理特征之一。APP信號通路涉及多種酶的參與,包括α、β和γ-分泌酶。這些酶的活性和調控對APP代謝產物的生成和去除至關重要。在研究和臨床應用方面,APP和其代謝產物被廣泛用于阿爾茨海默病的診斷和治療研究。

熱銷產品

APP Recombinant Monoclonal Antibody (Code:CSB-RA994273A0HU)

驗證數據

WB
CSB-RA994273A0HU WB

Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate, HEK293 whole cell lysate, Rat Brain whole cell lysate, Mouse Brain whole cell lysate
All lanes: Amyloid beta A4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 87, 35, 77, 79, 79, 81, 83, 85, 86, 73, 85 kDa
Observed band size: 100 kDa

IF
CSB-RA994273A0HU IF

Immunofluorescence staining of Hela Cells with CSB-RA994273A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).


APP Antibodies

APP for Homo sapiens (Human)

APP Proteins

APP Proteins for Homo sapiens (Human)



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