ADIPOR2
脂聯素受體2（Adiponectin Receptor 2，簡稱ADIPOR2），也被稱為PAQR2或ACDCR2。它屬于孕激素和adipoQ受體家族，與G蛋白偶聯受體類似，擁有7個跨膜結構域，但膜上方向相反。ADIPOR2主要在肝臟和骨骼肌中表達，負責結合脂聯素，一種由脂肪細胞分泌的激素，激活AMPK和PPAR-α通路，促進脂肪酸氧化和葡萄糖攝取，從而改善胰島素抵抗并減少炎癥反應。ADIPOR2的功能特點包括調控糖脂代謝平衡、抑制肝臟糖異生以及增強線粒體功能。若ADIPOR2發生突變，可能導致受體功能喪失或減弱，引發代謝異常，如2型糖尿病、肥胖和非酒精性脂肪肝病（NAFLD）。
ADIPOR2基因多態性與代謝綜合征風險相關。當ADIPOR2過表達時，可增強胰島素敏感性并減少脂肪堆積；而低表達則可能加劇代謝紊亂，誘發高血糖和血脂異常。ADIPOR2還與其他基因相互作用，共同調控代謝途徑。目前，ADPN重組蛋白或其受體激活蛋白可能作為有效的干預形式，被開發為藥物，治療細胞和動物在疾病模型中的糖脂代謝紊亂，并在人體臨床試驗表現出抗糖尿病、抗動脈粥樣硬化和抗炎的潛力。此外，ADIPOR2還可能是糖尿病和冠心病等糖脂代謝異常疾病的標志物。
熱銷產品
ADIPOR2 Antibody (CSB-PA011355)
驗證數據
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA011355(ADIPOR2 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA011355(ADIPOR2 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
ADIPOR2 Antibodies
ADIPOR2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA001368GA01HU | ADIPOR2 Antibody | Human,Mouse,Rat | ELISA,WB,IP,IHC |
| CSB-PA011355 | ADIPOR2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA141929 | ADIPOR2 Antibody | Human,Mouse | ELISA,IHC |
ADIPOR2 Proteins
ADIPOR2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP768214HU1 CSB-EP768214HU1 CSB-BP768214HU1 CSB-MP768214HU1 CSB-EP768214HU1-B |
Recombinant Human Adiponectin receptor protein 2 (ADIPOR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF768214HU | Recombinant Human Adiponectin receptor protein 2 (ADIPOR2) | in vitro E.coli expression system |
ADIPOR2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP805321MO1 CSB-EP805321MO1 CSB-BP805321MO1 CSB-MP805321MO1 CSB-EP805321MO1-B |
Recombinant Mouse Adiponectin receptor protein 2 (Adipor2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF805321MO | Recombinant Mouse Adiponectin receptor protein 2 (Adipor2) | in vitro E.coli expression system |
