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ADAM9

ADAM9(A disintegrin and metalloprotease 9),即含有脫氨酸和金屬蛋白酶結構域的蛋白9,是一種多功能的膜錨定蛋白,參與了多種生理過程。它由信號肽、金屬蛋白酶結構域、脫氨酸結構域、富含半胱氨酸的結構域和類表皮生長因子樣結構域組成。ADAM9在高爾基體運輸至細胞膜的過程中,通過去除其抑制性原結構域而被激活,這一裂解過程由furin或前蛋白轉化酶在兩個PC位點進行。ADAM9的功能涉及細胞粘附、細胞表面蛋白的脫落,以及在發育、炎癥和退行性疾病中的作用。特別地,ADAM9在腫瘤生物學中扮演著關鍵角色,其在多種癌癥中的過表達與腫瘤的侵襲性和不良預后密切相關。ADAM9通過蛋白水解和非蛋白水解途徑促進腫瘤的進展、治療抗性和轉移。它能夠識別并釋放膜結合的細胞因子和生長因子的胞外片段,同時參與受體和其他分子的信號轉導。ADAM9在腫瘤增殖、血管生成和免疫逃逸等多個腫瘤過程中發揮作用。因此,ADAM9已成為炎癥性疾病和癌癥治療中的潛在生物標志物和治療靶點,針對其的治療策略包括ADC藥物、單克隆抗體和小分子抑制劑等正在開發中。

熱銷產品

Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9),Partial (Active) (CSB-MP618774HU)

驗證數據

CSB-MP618774HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP618774HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ADAM9 at 2 μg/ml can bind Anti-ADAM9 recombinant antibody (CSB-RA618774MA1HU). The EC50 is 0.9401-1.088 ng/mL.

Recombinant Macaca fascicularis ADAM metallopeptidase domain 9 (ADAM9), partial (Active) (CSB-MP7133MOVd7)

驗證數據

CSB-MP7133MOVd7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP7133MOVd7

Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis ADAM9 at 2 μg/ml can bind Anti-ADAM9 recombinant antibody (CSB-RA618774MA1HU).The EC50 is 1.329-1.813 ng/mL.

ADAM9 Antibody (CSB-PA618774ESR1HU)

驗證數據

CSB-PA618774ESR1HU

Western blot
All lanes: Disintegrin and metalloproteinase domain-containing protein 9 antibody at 2μg/ml
Lane 1: Mouse liver tissue
Lane 2: Mouse heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 91, 73 kDa
Observed band size: 91 kDa

CSB-PA618774ESR1HU

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA618774ESR1HU at dilution of 1:100

CSB-PA618774ESR1HU

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA618774ESR1HU at dilution of 1:100

ADAM9 Antibodies

ADAM9 for Homo sapiens (Human)

ADAM9 Proteins

ADAM9 Proteins for Homo sapiens (Human)

ADAM9 Proteins for Mus musculus (Mouse)

ADAM9 ELISA Kit

ADAM9 ELISA Kit for Homo sapiens (Human)



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