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PPARG

PPARG,即過(guò)氧化物酶體增殖物激活受體γ,別名PPARgamma2、Nr1c3等。PPARG由人類PPARG基因編碼,該基因位于第3號(hào)染色體的3p25位置,全長(zhǎng)146,484bp,有多種不同形式的mRNA和兩種形式的蛋白質(zhì),分別由476個(gè)和505個(gè)氨基酸殘基構(gòu)成。PPARG的作用機(jī)制涉及與配體結(jié)合后激活,進(jìn)而影響脂肪細(xì)胞分化、脂肪酸代謝、糖代謝等過(guò)程。PPARG在調(diào)節(jié)細(xì)胞分化、調(diào)控細(xì)胞大分子生物合成過(guò)程以及對(duì)維生素的反應(yīng)中起關(guān)鍵作用,其表達(dá)變化或突變與腫瘤的發(fā)生有關(guān),且在前列腺癌形成中具有原癌基因的作用。PPARG還在多種疾病的發(fā)生發(fā)展中發(fā)揮作用,包括急性腎功能衰竭、動(dòng)脈疾病、胰腺炎、多囊腎和短暫性腦缺血等。

熱銷產(chǎn)品

Recombinant Human Peroxisome proliferator-activated receptor gamma (PPARG) (CSB-EP018424HU)

驗(yàn)證數(shù)據(jù)

CSB-EP018424HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PPARG Antibody (CSB-PA018424LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA018424LA01HU

IHC image of CSB-PA018424LA01HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA018424LA01HU

Immunofluorescence staining of PC-3 cells with CSB-PA018424LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

PPARG Antibodies

PPARG for Homo sapiens (Human)

PPARG Proteins

PPARG Proteins for Homo sapiens (Human)

PPARG Proteins for Mus musculus (Mouse)

PPARG Proteins for Oryctolagus cuniculus (Rabbit)

PPARG Proteins for Bos taurus (Bovine)

PPARG Proteins for Macaca mulatta (Rhesus macaque)

PPARG Proteins for Sus scrofa (Pig)

PPARG Proteins for Rattus norvegicus (Rat)

PPARG Proteins for Xenopus laevis (African clawed frog)

PPARG Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

PPARG Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

PPARG ELISA Kit

PPARG ELISA Kit for Homo sapiens (Human)

PPARG ELISA Kit for Mus musculus (Mouse)

PPARG ELISA Kit for Rattus norvegicus (Rat)



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