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GLP1R

GLP1R,全稱為胰高血糖素樣肽-1受體,是調(diào)節(jié)血糖的重要因子。它廣泛分布于胰島β細胞、胃、小腸、心臟、腎臟、肺等組織器官中。當GLP1R被胰高血糖素樣肽-1(GLP-1)或人工合成的GLP-1R激動劑激活后,能夠促進胰島素分泌,抑制胰高血糖素分泌,減緩胃腸動力,增加飽腹感,從而發(fā)揮多種生理功能。GLP1R蛋白也被稱為GLP-1受體的別名。近年來,GLP1R受體激動劑成為治療2型糖尿病和肥胖癥的重要藥物靶點,如司美格魯肽、利拉魯肽等。目前,全球范圍內(nèi)已有多種GLP-1R激動劑藥物獲批上市,為患者提供了更多的治療選擇。此外,GLP1R受體激動劑在治療非酒精性脂肪性肝炎、阿爾茨海默病等疾病方面也展現(xiàn)出一定的潛力。隨著對GLP1R蛋白研究的深入,其作用機制和臨床應(yīng)用將得到進一步拓展。

熱銷產(chǎn)品

Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) (CSB-MP009514HUb1)

驗證數(shù)據(jù)

CSB-MP009514HUb1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009514HUb1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.

Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial (Active) (CSB-MP009514MO1)

驗證數(shù)據(jù)

CSB-MP009514MO1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009514MO1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Glp1r at 2 μg/ml can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA3HU). The EC50 is 141.7-172.4 ng/mL.

Recombinant Macaca fascicularis Glucagon-like peptide 1 receptor (GLP1R), partial (Active) (CSB-MP4826MOV)

驗證數(shù)據(jù)

CSB-MP4826MOV

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP4826MOV

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis GLP1R at 2 μg/ml can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA2HU). The EC50 is 1.292-1.518 ng/mL.

Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), patial (Active) (CSB-MP009514RA2)

驗證數(shù)據(jù)

CSB-MP009514RA2

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009514RA2

Activity
Measured by its binding ability in a functional ELISA. Immobilized Rat Glp1r at 2 μg/ml can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA2HU). The EC50 is 8.630-10.66 ng/mL.

GLP1R Recombinant Monoclonal Antibody (CSB-RA009514MA1HU)

驗證數(shù)據(jù)

CSB-RA009514MA1HU

The Binding Activity of GLP1R with anti-GLP1R antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R(CSB-MP009514HUb1) at 2 μg/mL can bind Anti-GLP1R recombinant antibody, the EC50 is 54.54-94.23 ng/mL.

CSB-RA009514MA1HU

Untransfected HEK-293T cells surface (green line) and transfected Human GLP1R HEK-293T stable cells surface (red line) were stained with anti-GLP1R antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA009514MA1HU

Positive WB detected in: MCF-7 whole cell lysate(30μg),Mouse Heart tissue lysate(30μg),Rat Heart tissue lysate(30μg)
All lanes: GLP1R antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
Exposure time: 300s

GLP1R Antibody (CSB-PA009514YA01HU)

驗證數(shù)據(jù)

CSB-PA009514YA01HU

Western Blot
Positive WB detected in: U87 whole cell lysate(30μg), SHSY5Y whole cell lysate(30μg), 293T whole cell lysate(30μg), COLO205 whole cell lysate(30μg), Hela whole cell lysate(30μg), JK whole cell lysate(30μg),Mouse Heart tissue lysate(30μg),Mouse Brain tissue lysate(30μg)
All lanes: GLP1R antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
Exposure time: 120s

CSB-PA009514YA01HU

Immunofluorescence staining of HepG2 cell with CSB-PA009514LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA009514YA01HU

Immunofluorescence staining of HepG2 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

GLP1R Antibodies

GLP1R for Homo sapiens (Human)

GLP1R for Mus musculus (Mouse)

GLP1R Proteins

GLP1R Proteins for Rattus norvegicus (Rat)

GLP1R Proteins for Mus musculus (Mouse)

GLP1R Proteins for Homo sapiens (Human)

GLP1R Proteins for Homo sapiens(Human)

GLP1R ELISA Kit

GLP1R ELISA Kit for Mus musculus (Mouse)