AKT2
AKT2，即蛋白激酶Bβ，是一種在細(xì)胞內(nèi)信號傳導(dǎo)中發(fā)揮重要作用的絲氨酸/蘇氨酸激酶。AKT2主要在胰島素敏感的組織如骨骼肌、脂肪和肝臟中表達(dá)，是PI3K/AKT信號通路的關(guān)鍵組成部分。其作用機(jī)制涉及PI3K產(chǎn)生的PIP3，該物質(zhì)能夠招募AKT2至細(xì)胞膜，并通過磷酸化激活A(yù)KT2。激活后的AKT2能夠磷酸化多種底物，包括FOXO轉(zhuǎn)錄因子、mTOR復(fù)合體等，從而調(diào)控細(xì)胞的生長、代謝、存活和凋亡。AKT2參與的信號通路包括胰島素信號通路、IGF-1信號通路等，這些通路在調(diào)節(jié)細(xì)胞對營養(yǎng)物質(zhì)的吸收、利用以及能量平衡中起著核心作用。AKT2還與細(xì)胞周期的調(diào)控、細(xì)胞應(yīng)激反應(yīng)和細(xì)胞遷移等過程密切相關(guān)。在生物學(xué)意義上，AKT2對于維持細(xì)胞的正常生理功能和代謝平衡至關(guān)重要。其異常激活與2型糖尿病、肥胖和某些類型的癌癥等代謝性疾病和腫瘤的發(fā)生發(fā)展有關(guān)，是這些疾病治療中的潛在靶點。
熱銷產(chǎn)品
Recombinant Mouse RAC-beta serine/threonine-protein kinase (Akt2) (CSB-EP717138MO)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
AKT2 Antibody (CSB-PA15919A0Rb)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Rat liver tissue
All lanes: AKT2 antibody at 2.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56, 52 kDa
Observed band size: 56 kDa
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA15919A0Rb at dilution of 1:100
Immunofluorescence staining of A549 cells with CSB-PA15919A0Rb at 1:466, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
AKT2 Antibodies
AKT2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA15919A0Rb | AKT2 Antibody | Human, Rat | ELISA, WB, IHC, IF |
| CSB-PA15919D0Rb | AKT2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA922213 | Phospho-AKT2 (Ser474) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA215240 | AKT2 (Ab-474) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000469 | Phospho-AKT2 (S474) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA000859 | AKT2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA080247 | AKT2 Antibody | Human,Mouse,Rat | WB, IHC |
| CSB-PA617669 | AKT2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA090961 | AKT2 Antibody | Human,Mouse,Rat | ELISA,IHC |
AKT2 Proteins
AKT2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001555HU CSB-BP001555HU CSB-MP001555HU CSB-EP001555HU-B |
Recombinant Human RAC-beta serine/threonine-protein kinase (AKT2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP001555HU | Recombinant Human RAC-beta serine/threonine-protein kinase (AKT2), partial | E.coli |
AKT2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001555RA CSB-EP001555RA CSB-BP001555RA CSB-MP001555RA CSB-EP001555RA-B |
Recombinant Rat RAC-beta serine/threonine-protein kinase (Akt2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AKT2 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP653630DOA CSB-EP653630DOA CSB-BP653630DOA CSB-MP653630DOA CSB-EP653630DOA-B |
Recombinant Arabidopsis thaliana Potassium channel AKT2/3 (AKT2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AKT2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP717138MO CSB-BP717138MO CSB-MP717138MO CSB-EP717138MO-B |
Recombinant Mouse RAC-beta serine/threonine-protein kinase (Akt2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
