1. Study found reduced miR-326 levels concomitant with elevated Ucn1 levels in Edinger-Westphal nucleus (EWcp) of depressed suicide completers and in the EWcp of depressed rats. In fully recovered rats, both serum and EWcp miR-326 levels rebounded to nonstressed levels. While downregulation of miR-326 levels in primary midbrain neurons enhanced Ucn1 expression levels, miR-326 overexpression selectively reduced its levels. PMID: 27045550
2. urocortin may play a cytoprotective role in the germ cells in response to ischemia-reperfusion injury through the activation of major anti-apoptotic proteins, as well as by the mitogen-activated protein kinase signaling pathway activation. PMID: 27659706
3. Results suggest that sex differences exist in the distribution of UCN-1 within brainstem autonomic areas, and circulating level of estrogen may play an important role with regards to the function of these UCN-1 neurons during stress responses PMID: 26146233
4. UCN might contribute to regulate late midbrain dopaminergic neuron differentiation during ventral midbrain development. PMID: 25641682
5. UCN, CRHR1 and CRHR2 are expressed in the rat epididymis. It is suggested that CRH-related peptides might play multiple roles in the maturation and storage of spermatozoa. PMID: 24856473
6. Urocortin-1 expressing premotor neurons are located within the Edinger-Westphal nucleus. PMID: 23707488
7. Ucn1 is a contributory factor to the gender disparity in vasculitis and dihydrotestosterone-promoted Ucn1 secretion exacerbated the development of vasculitis. PMID: 24064363
8. Ucn1 induces a CRF2 mediated increase in circulating ghrelin via indirect actions on gastric ghrelin cells that involves a nicotinic pathway independently from the hyperglycemic response. PMID: 23183626
9. The two hypertrophic peptides urotensin II and urocortin stimulate the expression of myostatin. PMID: 22244812
10. Urocortin derived from dopaminergic neurons is involved in an autocrine protective signaling mechanism. PMID: 19875195
11. No effects of stress on corticotropin releasing hormone (CRF) and Ucn1 contents are seen in wild-type rat brain, but in Brattleboro rats, stress increases CRF contents in the paraventricular nucleus. PMID: 21621194
12. Acute pain stress resulted in the activation of urocortin-immunoreactive neurons in the Einger-Wesphal nucleus, peaking at 4 h after acute pain stress. PMID: 22432129
13. CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise PMID: 21627635
14. UcnI alone suppresses appetite and promotes fat oxidation and reliably suppresses food intake. PMID: 21303672
15. Ucn mRNA levels fell below basal levels in association with an increase in the number of Ucn1 immunoreactive inflammatory cells PMID: 21330446
16. Ucn 1 mRNA expression was higher in the restraint group than in the foot shock group. PMID: 20833218
17. Changes of somatic angiotensin-converting enzyme activity and production of other renin-angiotensin system components may play roles in the vasodilatory property of Ucn via activation of the extracellular signal-regulated kinase 1/2 pathway. PMID: 20237592
18. The rsults of this study proposed that the rate of axonal Ucn1 transport and, possibly, the strength of Ucn1 secretion, are dependent on sex to the same degree as is Ucn1 biosynthesis. PMID: 19833156
19. Ucn1 exerts pro-inflammatory effects by augmenting LPS-induced expression of COX-2 and ICAM-1 in RAECs via CRF(2) receptors and the activation of p38MAPK and NF-kappaB. PMID: 19694731
20. Data show that Ucn1's effect on L(p) is partially mediated by the CRH-R(2) receptor and acts independently of the c-JUN N-terminal kinase signal transduction pathway. PMID: 19819946
21. the inhibition of somatodendritic dopamine release by urocortin may be one of the molecular mechanisms underlying the effect of stress on motor function. PMID: 19729048
22. Ucn may play a key role in the response of the cardiovascular system to stress and a potent suppressor of appetite/feeding behaviour. PMID: 12007627
23. urocortin has a role in hypertrophy of rat cardiomyocytes as measured by an increase in cell area and enhanced protein: DNA ratio PMID: 12027405
24. The modulatory effects of the CRF-related peptide urocortin on memory and learning are mediated via CRF1 receptors. PMID: 12376180
25. urocortin enjoys a close ligand-receptor symmetry in the cerebellum, probably to a greater degree than corticotropin-releasing factor since corticotropin-releasing factor itself is found exclusively in the two major cerebellar afferent systems. PMID: 12379245
26. both Ucn and Ucn II induced accumulation of intracellular cAMP via corticotropin-releasing factor receptor type 2beta and also caused a significant increase in IL-6 output levels. PMID: 12746280
27. Urocortin is not only involved with the processing of sensory information conveyed within cerebellar afferents, but also with signals leaving the cerebellar cortex via Purkinje cells. PMID: 15024751
28. These findings suggest an interaction between Urocortin and NO signaling within the supraoptic nucleus, rather than the paraventricular, that may modulate the regulation of feeding, reproduction, and anxiety-related behaviors. PMID: 15457505
29. Results suggest that the urocortin gene locus naturally undergoes bidirectional transcription yielding a sense and an antisense RNA. PMID: 15979199
30. CRF treatment results in a clustered distribution of GluRdelta2 along the postsynaptic density, whereas UCN treatment provides a linear distribution. PMID: 16198122
31. CRF, UCN1, UCN2, and CRF1 and CRF2 receptors play a major role in the regulatory mechanisms that underlie the neural control of gastric motility through CRF2 receptor PMID: 16337313
32. sustained reduction in body weight and increased responsiveness to subsequent stressors in rats that have been exposed to repeated restraint are not associated with prolonged changes in mRNA expression of CRF receptors or their ligands PMID: 16423352
33. UCN in lung may act as a possible local autocrine and paracrine immune-inflammatory mediator in inflammatory airway of allergic asthma rats PMID: 16427607
34. In rats exposed to the social interaction test, urocortin 1 treatment increased the number of c-Fos serotonergic neurons within both the dorsal raphe nucleus and median raphe nucleus. PMID: 16488545
35. Natural occurrence of a polyadenylated intron-retained urocortin 1 RNA is documented in three brain regions: a midbrain region containing the Edinger-Westphal nucleus, in the cerebellum and in the prefrontal cortex. PMID: 16650605
36. Our data demonstrate the presence of urocortin and its receptors in rat Kupffer cells, the absence of corticotropin-releasing hormone, and the functionality of these receptors. PMID: 17090973
37. NPY, via NPY Y5 and to a lesser extent via the Y1 receptors, exerts a stimulatory action on Ucn1 cells in the nonpreganglionic Edinger-Westphal nucleus. PMID: 17154253
38. Results indicate that the hormonal status of the female rat affects urocortin 1 immunoreactive neurons in the non-preganglionic Edinger-Westphal nucleus and its signaling to target brain areas. PMID: 17391780
39. Data show in cultured RBE4 cerebral microvessel endothelial cells that urocortin endocytosis is increased by leptin in a time- and dose-dependent manner. PMID: 17478891
40. Acute UCN treatment protects the heart from reperfusion injury by inhibiting opening of the mitochondrial permeability transition pore, involving a PKC-mediated reduction in oxidative stress. PMID: 17483234
41. UCN is capable of maintaining adequate nigrostriatal function in vivo, via corticotrophin releasing hormone (CRF)1 receptors following a neuro-inflammatory challenge. PMID: 17659087
42. endogenous UCN and its receptors might be involved in a complex network of paracrine interaction between dopaminergic neurons and glia PMID: 17947696
43. Our results suggest that Ucn I in the NTS may play an important role in cardiovascular regulation and the cardiovascular effects of Ucn I may be mediated by activation of both CRF-R1 and -R2, which are known to be present in the NTS. PMID: 18804421
44. activation of CRF(2)receptor in the solitary nucleus, by Ucn1 and Ucn3, releases glutamate, which, in turn, elicits decreases in blood pressure and heart rate via activation of iGLURs PMID: 19395554

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KEGG: rno:29151

STRING: 10116.ENSRNOP00000008037

UniGene: Rn.10190