Recombinant Rat Tyrosine-protein kinase Mer (Mertk), partial

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中文名稱：

大鼠Mertk重組蛋白
品名簡稱：

Recombinant Rat Mertk protein, partial
貨號：

CSB-MP013706RA
說明書：

MSDS Datasheet
規(guī)格：

￥3960
圖片：
Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP013706RA could indicate that this peptide derived from Mammalian Cell-expressed Rattus norvegicus (Rat) Mertk.

Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP013706RA could indicate that this peptide derived from Mammalian Cell-expressed Rattus norvegicus (Rat) Mertk.

The purity of Mertk was greater than 95% as determined by SEC-HPLC

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
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靶點詳情

產(chǎn)品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
Greater than 95% as determined by SEC-HPLC.
基因名：

Mertk
Uniprot No.：

P57097
別名：

Mertk; MerTyrosine-protein kinase Mer; EC 2.7.10.1; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
來源：

Mammalian cell
分子量：

55.5
表達區(qū)域：

19-497aa
氨基酸序列

GGTAEKEEEIKPDQPFSGPLPGSLPADHRPFFAPHSSGDQLSPSQTGRSHPAHTATPQMTSAASNLLPPVAFKNTIGRIVLSEHKSVKFNCSINIPNVYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSITSVQRSDNGSYICKMKVNDREVVSDPIYVEVQGLPYFTKQPESVNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNENPERSPSVLTVAGLTETAVFSCEAHNDKGLTVSKGVQINIKVIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADQLSNGSVMVFNTSASPHLYEVQQLQALANYSVTVSCRNEIGWSAVSPWILASTTEGAPAVAPLNITVFLNESSNNLEIRWTKPPIKRQDGELVGYRISHVWESAGTSKELSEEVSQNGSWAQVPVQMHNATCTVRIAVITKGGIGPFSEPVDVAIPEHSRVDYAPSSTPAPGNTESM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Tris-based buffer，50% glycerol
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
基因功能參考文獻：
1. Mertk protein expression in the Bone marrow mesenchymal stem cells was similar to that in the retinal pigment epithelial cells in the primary passage. PMID: 28210098
2. study concludes that activated microglia release Gal-3 and a neuraminidase that desialylates microglial and PC12 surfaces, enabling Gal-3 binding to PC12 (neuron-like) cells and their phagocytosis via Mer tyrosine kinase (MerTK). PMID: 28500071
3. This study demonstrated that in Mertk mutation mice regulated the Expression pattern of Ccr2 and Cx3cr1. PMID: 26458944
4. A novel role of MERTK signaling in membrane trafficking in the Retinal Pigment Eepithelium that is likely to subserve mechanisms of phagosome formation. PMID: 26283020
5. A deletion in the Mer tyrosine kinase (MerTK) receptor in Royal College of Surgeons rat that abolishes internalization of photoreceptor outer segments by retinal pigment epithelial cells. PMID: 20238011
6. Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells. PMID: 11861639
7. Key involvement of mer in outer segment phsgocytosis has been clearly proven. PMID: 15180281
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相關疾病：

Defects in Mertk are the cause of retinal dystrophy (rdy) in the royal college of surgeons (RCS) rats.
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily
數(shù)據(jù)庫鏈接：

KEGG: rno:65037

STRING: 10116.ENSRNOP00000023419

UniGene: Rn.48789