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  4. Recombinant Mouse Transcription factor AP-2 gamma (Tfap2c)

Recombinant Mouse Transcription factor AP-2 gamma (Tfap2c)

  • 中文名稱：
    小鼠Tfap2c重組蛋白
  • 貨號：
    CSB-YP713969MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Tfap2c重組蛋白
  • 貨號：
    CSB-EP713969MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Tfap2c重組蛋白
  • 貨號：
    CSB-EP713969MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Tfap2c重組蛋白
  • 貨號：
    CSB-BP713969MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Tfap2c重組蛋白
  • 貨號：
    CSB-MP713969MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Tfap2c
  • Uniprot No.：
  • 別名：
    Tfap2c; Tcfap2c; Transcription factor AP-2 gamma; AP2-gamma; AP-2.2; Activating enhancer-binding protein 2 gamma
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-449
  • 氨基酸序列
    MLWKITDNVK YEEDCEDRHD SSSNGNPRIP HLSSPGQHLY SPAPPLSHTG VAEYQPPPYF PPPYQQLAYS QSADHYSHLG EAYAAAMNPL HQPAATGSQQ QAWPGRQSQE GSSLASHHSR SASLIPHISG LEGGSVSARR EVYRRSDLLL PHAHALEAGL AENLGLHEMA HPIEEVQNVD DAHLLLHDQT VIRKGPISMT KNPLGLPCQK DLVGVVMNPS EVFCSVPGRL SLLSSTSKYK VTVAEVQRRL SPPECLNASL LGGVLRRAKS KNGGRSLREK LDKIGLNLPA GRRKAAHVTL LTSLVEGEAV HLARDFAYVC EAEFPSKAVA DYLTRPHLGG RNEMATRKSM LLAAQQVCKE FTDLLHQDRT PNGNNRPAQV LEPNIQNCLS HFSLITHGFG SQAICAAVSA VQNYIKEALI AIDKSYMNPG DQSPADSSKT MEKMEKHRK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.
  • 基因功能參考文獻：
    1. TFAP2C in trophoblasts controls proliferation by repressing Cdkn1a and activating the MAPK pathway, further supporting differentiation of glycogen cells by activating the AKT pathway PMID: 26811378
    2. these findings indicate that a reduction in the gene dosage of placental Tfap2c leads to morphological changes in the labyrinth at midgestation PMID: 26063869
    3. TFAP2C regulates tumorigenesis, cell growth and survival in HER2-amplified breast cancer through transcriptional regulation of EGFR. PMID: 25772240
    4. Tcfap2c acts in a hierarchy to facilitate blastocyst formation through transcriptional regulation of core genes involved in tight junction assembly, fluid accumulation and cellular proliferation PMID: 23136388
    5. Transcription factor AP-2gamma induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage. PMID: 25858457
    6. we characterize the cis-regulatory organization of a large genomic locus consisting of Tfap2c and Bmp7. We show that this locus is structurally partitioned into two distinct domains by the constitutive action of a discrete transition zone PMID: 25569170
    7. mice with a heterozygous deletion of the TFAP2C target gene Nanos3 are also prone to develop teratomas. These data highlight TFAP2C as a critical and dose-sensitive regulator of germ cell fate. PMID: 23967156
    8. Tcfap2c is not required for Oct4 silencing in mouse blastocysts, but may be necessary for the maintenance of Oct4 expression during the 8 cell-to-morula transition. PMID: 23741512
    9. results substantiate a role for Tcfap2c/ TFAP2C in supporting proliferation and repressing differentiation in cellular compartments representing immature/ progenitor cells[review] PMID: 22560121
    10. study demonstrated clearly that nuclear expression of transcription factor Ap-2gamma is a useful marker for identifying undifferentiated male germ cells PMID: 21654158
    11. In intestine, Tcfap2c induced cellular hyperplasia and suppressed terminal differentiation indicating that Tcfap2c serves as a repressor of differentiation and inducer of proliferation. PMID: 21779369
    12. Expression of AP-2gamma transcription factors in breast cancer cells supports proliferation and contributes to chemo- and radiation-resistance of tumor cells by impairing the ability to induce apoptosis. PMID: 20459791
    13. AP-2gamma is functionally involved in branching morphogenesis of the mammary epithelium, possibly by controlling genetic processes downstream of ovarian hormones PMID: 20131354
    14. Data suggest that Tcfap2c and Cdx2 cooperate to override the pluripotency program and establish the extraembryonic trophoblast maintenance program in murine embryos. PMID: 20404091
    15. important effector of Prdm1 activity that is required for primordial germ cell maintenance PMID: 19776388
    16. AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI. PMID: 11773066
    17. Transcription factor gene AP-2 gamma essential for early murine development PMID: 11940672
    18. essential in the extra-embryonic lineages for early postimplantation development PMID: 12015300
    19. we have identified a potential trophoblast cell-specific regulatory element located 6 kb upstream of the murine AP-2gamma gene transcription start site, and that Sp1 and Sp3 bind to cis-regulatory elements located in the promoter proximal region PMID: 12801994
    20. Our results suggest a role of AP-2 transcription factors in the maintenance of a proliferative and undifferentiated state of cells, characteristics not only important during embryonic development but also in tumorigenesis. PMID: 14573793
    21. These results document an important role for AP-2 gamma in skin development, and reveal the existence of regulatory factors that can compensate for AP-2 gamma in its absence. PMID: 18353300
    22. AP2gamma acts as a regulator of basal progenitor fate, linking regional and laminar specification in the mouse developing cerebral cortex. PMID: 19749747
    23. Mice overexpressing AP-2gamma in the mammary epithelial cells display hyperproliferation counterbalanced by enhanced apoptosis leading to hypoplasia. In males, differentiation of seminal vesicles was impaired. PMID: 14573793
    24. Activating protein-2 assumes the role of steroidogenic factor-1 in the placenta and thereby mediates the transcription of cholesterol side-chain cleavage cytochrome p450. PMID: 12145340

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    AP-2 family
  • 組織特異性：
    Expressed in lung, ovary and testis. Expressed in most squamous epithelia. Also, detected in several exocrine glands including the prostate, the preputial and salivary glands, serous glands of the tongue and ocular harderian glands.
  • 數據庫鏈接：

    KEGG: mmu:21420

    STRING: 10090.ENSMUSP00000129922

    UniGene: Mm.3629