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  4. Recombinant Mouse Tescalcin (Tesc)

Recombinant Mouse Tescalcin (Tesc)

  • 中文名稱：
    小鼠Tesc重組蛋白
  • 貨號：
    CSB-YP023393MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Tesc重組蛋白
  • 貨號：
    CSB-EP023393MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Tesc重組蛋白
  • 貨號：
    CSB-EP023393MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Tesc重組蛋白
  • 貨號：
    CSB-BP023393MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Tesc重組蛋白
  • 貨號：
    CSB-MP023393MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Tesc
  • Uniprot No.：
  • 別名：
    Tesc; Chp3Calcineurin B homologous protein 3; Tescalcin; TE-1; TSC
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-214
  • 氨基酸序列
    GAAHSASEE VRELEGKTGF SSDQIEQLHR RFKQLSGDQP TIRKENFNNV PDLELNPIRS KIVRAFFDNR NLRKGSSGLA DEINFEDFLT IMSYFRPIDT TLGEEQVELS RKEKLKFLFH MYDSDSDGRI TLEEYRNVVE ELLSGNPHIE KESARSIADG AMMEAASVCV GQMEPDQVYE GITFEDFLKI WQGIDIETKM HIRFLNMETI ALCH
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
  • 基因功能參考文獻：
    1. TESC has an important role in mediating the neuroprotective effect of class I histone deacetylase inhibitors, and may also be involved in the development of brain and neurodegenerative diseases through epigenetic mechanisms PMID: 27939885
    2. Tescalcin does not appear to be necessary for normal megakaryocyte development PMID: 22285131
    3. the data demonstrated that Sp1 and Sp3 transcription factors cooperate positively in the regulation of Tesc promoter, and that the putative ZF5 motif is critical for its activation. PMID: 20540995
    4. Tescalcin shares sequence and functional homology with calcineurin-B homologous protein (CHP), and like CHP can inhibit the phosphatase activity of calcineurin A. PMID: 14661968
    5. Studies indicate very specific expression of Tesc in various tissues in chicken and mouse during embryologic development, and conservation of Tesc expression in both species. PMID: 19345287

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane.
  • 蛋白家族：
    Calcineurin regulatory subunit family, CHP subfamily
  • 組織特異性：
    Expressed in embryonic, newborn and adult testis, but not in prepubertal testis. Expressed in the embryonic testis during testis determination but is not expressed at any time in the embryonic ovary. In embryonic testis, expression is restricted to the te
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