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  4. Recombinant Mouse Receptor-type tyrosine-protein phosphatase R (Ptprr), partial

Recombinant Mouse Receptor-type tyrosine-protein phosphatase R (Ptprr), partial

  • 中文名稱：
    小鼠Ptprr重組蛋白
  • 貨號：
    CSB-YP733813MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ptprr重組蛋白
  • 貨號：
    CSB-EP733813MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ptprr重組蛋白
  • 貨號：
    CSB-EP733813MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ptprr重組蛋白
  • 貨號：
    CSB-BP733813MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ptprr重組蛋白
  • 貨號：
    CSB-MP733813MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ptprr; Ptp13; Receptor-type tyrosine-protein phosphatase R; R-PTP-R; EC 3.1.3.48; Phosphotyrosine phosphatase 13; Protein-tyrosine-phosphatase SL
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton.
  • 基因功能參考文獻：
    1. These findings indicate an important role for PTPRR in maintaining low basal mitogen-activated protein kinase activity in Purkinje cells. PMID: 25571783
    2. The data of this study disclosed a distinct role for PTPRR in recognition memory and exploration of a new environment. PMID: 24556203
    3. Results support the suggested link between PTPRR isoforms and cerebellar calcium ion homeostasis, and suggest an additional role in the process of cell-cell adhesion PMID: 21850207
    4. Multiple isoforms through the use of distinct promoters, alternative splicing and differential translation starts. PMID: 15461663
    5. The ERK2 docking groove is more restrictive and selective for its tyrosine phosphatase inactivators than for MEK1/2 and indicate that distinct ERK2 residues modulate the docking interactions with activating and inactivating effectors. PMID: 16148006
    6. PTPBR7, was subject to N-terminal proteolytic processing, in between amino acid position 136 and 137, resulting in an additional, 65-kDa transmembrane PTPRR isoform. PMID: 17147696
    7. Ptprr-/- mice displayed ataxia characterized by defects in fine motor coordination and balance skills. PMID: 17266727
    8. PTP-SL, like PTPBR7, is a single membrane-spanning receptor-type protein tyrosine phosphatases. PMID: 18068678

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  • 亞細胞定位：
    [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Beta]: Cytoplasm. Note=Locates to the areas within the cytoplasm.; [Isoform Gamma]: Cytoplasm. Note=Locates to the areas within the cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 7 subfamily
  • 組織特異性：
    Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform alpha is expressed throughout the granular layer of the cerebellar but not within the Purkinje cells, also in the villi of the ileum and jejunum and both the v
  • 數據庫鏈接：


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