Recombinant Mouse Protein Wnt-9b (Wnt9b)

中文名稱：

小鼠Wnt9b重組蛋白
貨號：

CSB-YP026146MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Wnt9b重組蛋白
貨號：

CSB-EP026146MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Wnt9b重組蛋白
貨號：

CSB-EP026146MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Wnt9b重組蛋白
貨號：

CSB-BP026146MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Wnt9b重組蛋白
貨號：

CSB-MP026146MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Wnt9b
Uniprot No.：

O35468
別名：

Wnt9b; Wnt14b; Wnt15; Protein Wnt-9b; Protein Wnt-14b; Protein Wnt-15
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

24-359
氨基酸序列

AAYFGLT GREVLTPFPG LGTAAAPAQA GAHLKQCDLL KLSRRQKQLC RREPGLAETL RDAAHLGLLE CQFQFRQERW NCSLEGRTGL LQRGFKETAF LYAVSAAALT HALARACSAG RMERCTCDDS PGLESRQAWQ WGVCGDNLKY STKFLSNFLG PKRGSKDLRA RADAHNTHVG IKAVKSGLRT TCKCHGVSGS CAVRTCWKQL SPFRETGQVL KLRYDTAVKV SSATNEALGR LELWAPAKPG GPAKGLAPRP GDLVYMEDSP SFCRPSKYSP GTAGRVCSRD SSCSSLCCGR GYDTQSRMVV FSCHCQVQWC CYVECQQCAQ QELVYTCKR
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development.
基因功能參考文獻：
1. Data indicate that mutations in wingless-type MMTV integration site family, member 9B protein (WNT9B) were frequently associated with Mayer-Rokitansky-Kuster-Hauser syndrome (MRKHS). PMID: 26610373
2. Epigenetic mechanism causes Wnt9b deficiency and nonsyndromic cleft lip and palate in the A/WySn mouse strain. PMID: 25257647
3. Expression of Wnt9b in Six2-positive cells disrupts cell fate decisions in the kidney and the gastrointestinal tract. PMID: 22912798
4. Epithelial Wnt7b and Wnt9b as possible ligands of Fzd1-mediated beta-catenin (Ctnnb1)-dependent (canonical) Wnt signaling in the undifferentiated ureteric mesenchyme PMID: 22833126
5. Study has identified a previously unknown regulatory link between WNT9B and FGF signaling during lip and upper jaw development. PMID: 22461561
6. Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells PMID: 21852398
7. transgenic overexpression of Wnt9b in the ureteric bud causes reduced branching in multiple founder lines. PMID: 20702564
8. expression in most but not all tissues of the 16.5-day embryo; no significant elevation of Wnt9b expression was detected in 29 mouse mammary tumor virus-induced tumors PMID: 12573259
9. Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system. PMID: 16054034
10. Signals through the canonical Wnt signaling pathway to regulate midfacial development and lip fusion. PMID: 16496313
11. The noncomplementation of clf1 and Wnt9b- confirms that clf1 is a mutation of the Wnt9b gene. PMID: 16998816
12. Findings show that Wnt9b, produced by the kidney collecting ducts, nonautonomously regulates morphogenesis of the developing kidney tubules. PMID: 19543268
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亞細胞定位：

Secreted, extracellular space, extracellular matrix. Secreted.
蛋白家族：

Wnt family
數(shù)據(jù)庫鏈接：

KEGG: mmu:22412

STRING: 10090.ENSMUSP00000018630

UniGene: Mm.215161