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  4. Recombinant Mouse Integrin alpha-4 (Itga4), partial

Recombinant Mouse Integrin alpha-4 (Itga4), partial

  • 中文名稱：
    Recombinant Mouse Integrin alpha-4 (Itga4), partial
  • 品名簡稱：
    Recombinant Mouse Itga4 protein, partial
  • 貨號：
    CSB-MP6511MO4
  • 說明書：
  • 規格：
    ￥1536
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 別名：
    CD49 antigen-like family member D;Integrin alpha-IV;Lymphocyte Peyer patch adhesion molecules subunit alpha;VLA-4 subunit alpha
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 來源：
    Mammalian cell
  • 分子量：
    124.0 kDa
  • 表達區域：
    41-550aa
  • 氨基酸序列
    YNLDPENALLYQGPSGTLFGYSVVLHSHGSKRWLIVGAPTASWLSNASVVNPGAIYRCGIRKNPNQTCEQLQSGSPSGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYMKSDNKLPTGICYVMPSDLRTELSKRMAPCYKDYTRKFGENFASCQAGISSFYTQDLIVMGAPGSSYWTGTVFVYNITTNQYKAFVDRQNQVKFGSYLGYSVGAGHFRSPHTTEVVGGAPQHEQIGKAYIFSIDENELNIVYEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGMGAVMVEMERVLVGSDKYAARFGESIANLGDIDNDGFEDIAIGAPQEDDLRGAVYIYNGRVDGISSTYSQRIEGQQISKSLRMFGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLSHPESVNRTKFDCTENGLPSVCMHLTLCFSYKGKEVPGYIVLFYNVSLDVHRKAESPSRFYFFSNGTSDV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 10xHis-HSA-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.
  • 基因功能參考文獻：
    1. the data suggest that CXCR3 and the integrin alpha4 mediate T cell recruitment to uninfected salivary glands but that redundant mechanisms mediate T cell recruitment after Murine Cytomegalovirus infection. PMID: 29288198
    2. As blockade of PI3Kgamma or integrin alpha4 prevents accumulation of myeloid-derived suppressor cells and reduces myeloid cell expression of immunosuppressive factors that stimulate tumor immune escape, these results highlight PI3Kgamma and integrin alpha4 as targets for the design of cancer therapeutics. PMID: 28963139
    3. integrin alpha4beta1 mediates the inhibitory effect of oncofetal Fibronectin both in vitro as well as in vivo. PMID: 27427791
    4. investigation of the role of alpha4 integrin and the therapeutic effect of HCA3551, a newly synthesized orally active small molecule alpha4 integrin antagonist, in the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease PMID: 27803063
    5. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD. PMID: 27543429
    6. Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1, respectively; expression of the latter was upregulated in obesity. PMID: 28414311
    7. uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology PMID: 27016608
    8. Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking. PMID: 28495929
    9. this study shows that alpha4beta1 integrin mediates memory CD8+ T cells accumulation in salivary glands after infection with lymphocytic choriomeningitis virus PMID: 27861803
    10. The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 interactions as drivers of colitis by directing inflammatory monocytes into the colon. PMID: 26349655
    11. Integrin a4b7 is essential for suppression of experimental colitis as it regulates the colonic Treg cell population and innate immunity. PMID: 26220167
    12. These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1. PMID: 26659448
    13. ITGA4 expression enhances metastasis in MYCN low neuroblastoma. PMID: 25973900
    14. investigated which alpha4beta1-integrin ligands expressed by endothelial cells are implicated PMID: 26358409
    15. Data indicate a role of integrin alpha4beta7 (alpha4beta7) in diet-induced atherosclerosis. PMID: 24970009
    16. CD49d-high-expressing Th1 memory phenotype CD4+ T cells with enhanced B cell helper activity develop early in the peritoneal cavity. PMID: 26056253
    17. Data suggest that bortezomib mobilizes hematopoietic stem cells (HSPCs) by modulation of the integrin alpha4beta1 (VLA)-4/vascular cell adhesion molecule-1 (VCAM-1) axis. PMID: 25342668
    18. Consistent with a role of alpha4beta7 in the generation of intestinal mononuclear phagocytes, bone marrow cells from beta7(-/-) mice poorly reconstituted small intestine retinoic acid (RA)-producing CD11c(hi) dendritic cells. PMID: 24030488
    19. alpha4 integrins whether deleted early or late have a dominant effect on bone marrow retention of erythroblasts and on terminal erythroid maturation at homeostasis and after stress. PMID: 24463276
    20. SP/drug efflux functionality of hematopoietic progenitors is controlled by mesenchymal niche through VLA-4/CD44 axis. PMID: 23999380
    21. We conclude that integrin alpha4beta1 is necessary for CD4(+) T cell-mediated protection against C. trachomatis infection in the genital mucosa. PMID: 24659687
    22. Mobilization of bone marrow-derived cells by G-CSF boosted migration along the VCAM-1/VLA-4 axis and reduced apoptosis of cardiomyocytes. PMID: 24065117
    23. How natalizumab binds and antagonizes alpha4 integrins PMID: 24047894
    24. PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth. PMID: 23565202
    25. expression in hematopoietic stem cells peaked at 48h following acute lung injury PMID: 23018206
    26. alpha(4) and alpha(9) integrins interacting with OPN via the SLAYGLR domain play a key role in macrophage biology by regulating migration, survival, and accumulation. PMID: 23192608
    27. Once activated, alpha4beta1 promotes lymph node lymphangiogenesis and facilitates adhesion of VCAM-1+ metastatic tumor cells within lymph nodes, thereby promoting tumor spread. PMID: 23671068
    28. In HSPCs, BMP4 directly regulates Integrin-alpha4 expression through SMAD-independent p38 MAPK-mediated signaling. PMID: 23243277
    29. The integrin subunits Itga4 (alpha4) and Itgal (Lfa1), as well as the selectin ligand Selplg (Psgl1), did not show differences in their expression in single LT-HSCs irrespective of the developmental times or anatomical microenvironments. PMID: 22276210
    30. SWAP-70 regulates erythropoiesis by controlling alpha4 integrin. PMID: 21880631
    31. Selective deletion of alpha4 integrin in T cells of knockout mice delays but does not prevent development of experimental autoimmune encephalomyelitis. PMID: 22084440
    32. EMILIN1 is identified as a novel ligand for keratinocyte alpha9beta1 integrin, suggesting prospective roles for this receptor-ligand pair in skin homeostasis. PMID: 21949412
    33. in S. pneumoniae infection, integrins Mac-1 and alpha4beta1 have pivotal role in prevention of pneumococcal outgrowth both in regulating neutrophil and T cell recruitment into infected lungs and influencing their behavior within the lung tissue itself PMID: 21460207
    34. Studies lends new insight to the distinct in vivo roles of alpha and alpha integrins in erythroid stress. PMID: 20956802
    35. Cell polarization in alpha4beta1-stimulated macrophages requires focal adhesion kinase to induce cellular elongation. PMID: 21084629
    36. role in migration of B cells into pancreatic lymph nodes in NOD mice PMID: 20488663
    37. data indicate that ITGA9-ITGB7 functions as an ADAM binding partner in certain cellular contexts, with implications for mammalian fertilization and integrin function PMID: 21060781
    38. Activated natural killer cells interact with tumor necrosis factor-alpha-stimulated endothelial cells to induce their proliferation and promote angiogenesis through a mechanism involving alpha4beta7 integrin and killer cell lectin-like receptor (KLRG)1. PMID: 20971926
    39. Chemerin-stimulated adhesion of peritoneal macrophages to fibronectin is dependent on increased avidity of integrin VLA-5 (alpha5ss1). PMID: 20720202
    40. demonstrate that FcepsilonRI expression on lung conventional dendritic cells depends on an unexpected activity of a CD49d(+) subset of polymorphonuclear neutrophils PMID: 20876348
    41. CD49d-positive expression identifies a distinct subpopulation of myeloid-derived suppressor cells that negatively regulates antigen-specific T cell responses through a nitric oxide-dependent mechanism. PMID: 20525890
    42. Using an ex vivo flow cytometry assay, the authors found that simian immunodeficiency virus mac239-infected cells expressed significantly lower levels of integrin alpha4beta7 than did uninfected cells. PMID: 20410278
    43. These studies suggest that beta1, but not alpha4, integrin of VLA-4 is the sex-specific molecule on T cell surface PMID: 20483780
    44. Data show that the preferential pairing of beta1 integrin with alpha4 integrin regulates the expression of alpha4beta7 on T PMID: 20118278
    45. alpha4beta1-mediated tumor lymphangiogenesis promotes metastasis PMID: 20388801
    46. alpha(4) integrin expressed by melanoma cells contributes to tumorigenesis and may also facilitate metastasis to regional lymph nodes PMID: 20126475
    47. a small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation PMID: 20097761
    48. show that alpha4 integrins and VCAM-1 play essential roles in mediating the accumulation of IgA antibody secreting cells to the lactating mammary gland. PMID: 20171738
    49. alpha(4) and alpha(5) integrin-dependent adhesion of BMPCs in lung tissue plays a critical role in preventing lung vascular injury and increasing survival in a mouse model of lipopolysaccharide-induced acute lung injury. PMID: 19839056
    50. Both LFA-1 and VLA-4 are involved in vasoendothelial adhesion and transendothelial migration of high proliferative potential endothelial progenitor cells. PMID: 18549652

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin alpha chain family
  • 組織特異性：
    Peyer patch homing cells.
  • 數據庫鏈接：