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  4. Recombinant Mouse Growth/differentiation factor 9 (Gdf9)

Recombinant Mouse Growth/differentiation factor 9 (Gdf9)

  • 中文名稱：
    Recombinant Mouse Growth/differentiation factor 9 (Gdf9)
  • 品名簡稱：
    Recombinant Mouse Gdf9 protein
  • 貨號：
    CSB-MP009352MO
  • 說明書：
  • 規(guī)格：
    ￥1536
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 別名：
    GDF-9;Gdf-9
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    Mammalian cell
  • 分子量：
    84.9 kDa
  • 表達區(qū)域：
    307-441aa
  • 氨基酸序列
    GQKAIRSEAKGPLLTASFNLSEYFKQFLFPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVRHRYGSPVHTMVQNIIYEKLDPSVPRPSCVPGKYSPLSVLTIEPDGSIAYKEYEDMIATRCTCR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 10xHis-HSA-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for ovarian folliculogenesis.
  • 基因功能參考文獻：
    1. The arginine residue in the pre-helix loop of GDF9 homodimer may prevent the inhibition from its pro-domain or directly alter receptor binding, but this residue in GDF9 does not significantly affect the heterodimer activity during heterodimer formation. PMID: 25253739
    2. A novel role for GDF9 in causing reproductive defects and suppressing tumor initiation in the Inha(-/-) mouse model. PMID: 23446452
    3. Embryo vitrification has no effect on ovarian morphology or expression of GDF9. PMID: 23141291
    4. The results show that chronic unpredictable stress suppresses GDF9 expression. PMID: 22205697
    5. GDF9 may contribute to the variation observed in follicular development, ovulation rate, and fecundity between mammals PMID: 22234469
    6. Data indicate that GDF-9 is absent in follicles of obese anovulatory/PCOS ovaries; upon treatment by heterotopic transplantation of gonadal adipose tissue from lean mice, expression of GDF-9 and ovulation appear to resume. PMID: 21557698
    7. E2 and oocyte-derived paracrine factors GDF9 and bone morphogenetic protein 15 coordinate to promote the development of cumulus cells PMID: 21047911
    8. GDF9-stimulated mitogenic activity in granulosa and cumulus cells is mediated through ERK1/2 activity. PMID: 20736313
    9. Intraovarian excess androgen in polycystic ovary syndrome may result in follicular arrest by down-regulating growth and differentiation factor-9 expression. PMID: 20032061
    10. Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility. PMID: 12040004
    11. GNCF-dependent repression of Gdf9 mediates gamete regulation of female fertility. PMID: 12912906
    12. Growing oocytes and GDF9 can each induce granulosa cells from secondary follicles to shift their phenotype toward that of mural granulosa cells. PMID: 14695909
    13. GDF9 appears to function indirectly to regulate early granulosa cell proliferation and theca recruitment in vivo PMID: 15016837
    14. the endogenous GDF9 protein is an important oocyte-secreted mitogen, but accounts for only part of total oocyte bioactivity. PMID: 15128595
    15. gremlin modulates the cross-talk between GDF9 and BMP signaling that is necessary during follicle development PMID: 15133038
    16. GDF9 is a key mediator of oocyte-enabled cumulus expansion in mice. PMID: 15385414
    17. Gdf9 has a role in the development and function of the oocyte-cumulus cell complex in mice. PMID: 15531364
    18. neither GDF9 nor TGFbeta alone, nor the two in unison, account for the critical oocyte-secreted factors regulating mouse cumulus expansion PMID: 15761035
    19. The E-box is a key regulatory sequence for Gdf9 expression in the ovary. PMID: 16495478
    20. The GDF9 immunostaining was exclusively seen in growing oocytes PMID: 16943361
    21. NOBOX directly regulates the transcription of Pou5f1 and Gdf9 in oocytes during early folliculogenesis PMID: 16997917
    22. Exogenous GDF9 during in vitro maturation(IVM) improved embryo development and fetal viability and provides a promising approach for human IVM. PMID: 17933754
    23. This study is the first characterization of purified biologically active human GDF9 and as such is of importance for studies on human fertility. PMID: 18162287
    24. Its promoter, stably transfected into XX mouse ES cells, showed increased expression by addition of leukemia inhibitory factor to the media. PMID: 18593614
    25. studies confirm GDF9 expression in the mouse testis, pituitary gland and adrenocortical cancer (AC) cells, and establish its expression in L beta T2 gonadotrophs, and in mouse adrenal glands, particularly foetal and neonatal cortical cells PMID: 19505950
    26. The highest Gdf9 mRNA levels were detected in oocytes in the pre-antral follicle stage. PMID: 19553355

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 組織特異性：
    Ovary.
  • 數(shù)據(jù)庫鏈接：


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