Recombinant Mouse Carbonyl reductase [NADPH] 1 (Cbr1)

中文名稱：

Recombinant Mouse Carbonyl reductase [NADPH] 1(Cbr1)
貨號(hào)：

CSB-YP004586MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

Recombinant Mouse Carbonyl reductase [NADPH] 1(Cbr1)
貨號(hào)：

CSB-EP004586MO
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

Recombinant Mouse Carbonyl reductase [NADPH] 1(Cbr1)
貨號(hào)：

CSB-EP004586MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Carbonyl reductase [NADPH] 1(Cbr1)
貨號(hào)：

CSB-BP004586MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Carbonyl reductase [NADPH] 1(Cbr1)
貨號(hào)：

CSB-MP004586MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cbr1
Uniprot No.：

P48758
別名：

Cbr1; CbrCarbonyl reductase [NADPH] 1; EC 1.1.1.184; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; EC 1.1.1.197; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase; EC 1.1.1.189
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-277
氨基酸序列

SSSRPVALV TGANKGIGFA ITRDLCRKFS GDVVLAARDE ERGQTAVQKL QAEGLSPRFH QLDIDNPQSI RALRDFLLKE YGGLDVLVNN AGIAFKVNDD TPFHIQAEVT MKTNFFGTRD VCKELLPLIK PQGRVVNVSS MVSLRALKNC RLELQQKFRS ETITEEELVG LMNKFVEDTK KGVHAEEGWP NSAYGVTKIG VTVLSRILAR KLNEQRRGDK ILLNACCPGW VRTDMAGPKA TKSPEEGAET PVYLALLPPD AEGPHGQFVQ DKKVEPW
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
基因功能參考文獻(xiàn)：
1. CBR1 plays a critical role in controlling redox balance and detoxifying lipid peroxidation during muscle differentiation and regeneration. PMID: 23732109
2. CBR1 attenuates apoptosis and promotes cell survival in pancreatic beta-cell lines under glucotoxic and glucolipotoxic conditions via reducing ROS generation PMID: 20728534
亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

Short-chain dehydrogenases/reductases (SDR) family
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:12408

STRING: 10090.ENSMUSP00000049394

UniGene: Mm.26940