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  4. Recombinant Mouse Alanine--glyoxylate aminotransferase 2, mitochondrial (Agxt2)

Recombinant Mouse Alanine--glyoxylate aminotransferase 2, mitochondrial (Agxt2)

  • 中文名稱：
    Recombinant Mouse Alanine--glyoxylate aminotransferase 2, mitochondrial(Agxt2)
  • 貨號：
    CSB-YP667565MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Alanine--glyoxylate aminotransferase 2, mitochondrial(Agxt2)
  • 貨號：
    CSB-EP667565MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Alanine--glyoxylate aminotransferase 2, mitochondrial(Agxt2)
  • 貨號：
    CSB-EP667565MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Alanine--glyoxylate aminotransferase 2, mitochondrial(Agxt2)
  • 貨號：
    CSB-BP667565MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Alanine--glyoxylate aminotransferase 2, mitochondrial(Agxt2)
  • 貨號：
    CSB-MP667565MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Agxt2
  • Uniprot No.：
  • 別名：
    Agxt2Alanine--glyoxylate aminotransferase 2; mitochondrial; AGT 2; EC 2.6.1.44,; R)-3-amino-2-methylpropionate--pyruvate transaminase; EC 2.6.1.40; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-AIBAT
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    41-513
  • 氨基酸序列
    LHTKHSMPPC DFSPEKYQSL AYSRVLAIHK QHLSPVDTAY FRKPLLLHQG HMEWLFDSEG NRYLDFFSGI VTVSVGHCHP KVSAVAKKQI DRLWHTSSVF FHSPMHEYAE KLSALLPEPL KVIFLVNSGS EANDLAMVMA RAHSNHTDII SFRGAYHGCS PYTLGLTNVG IYKMEVPGGI GCQSTMCPDV FRGPWGGIHC RDSPVQTVRD CSCAPDCCQA KERYIEQFKD TLNTSVATSI AGFFAEPIQG VNGVVQYPKE FLKEAFALVR ERGGVCIADE VQTGFGRLGS HFWGFQTHDV LPDIVTMAKG IGNGFPMAAV VTTPEIAKSL AKRLLHFSTF GGNPLACAIG SAVLEVIEEE NLQRNSQEVG TYMLLKFAKL RDEFDIVGDV RGKGLMVGIE MVQDKISRQP LPKTEVNQIH EDCKDMGLLV GRGGNFSQTF RIVPPMCVTK MEVDFAYEVF RAALIQHMER RAK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
  • 基因功能參考文獻：
    1. this study shows that diabetes-linked transcription factor HNF4alpha regulates maminotransferase 2etabolism of endogenous methylarginines and beta-aminoisobutyric acid by controlling expression of alanine-glyoxylate PMID: 27752141
    2. we experimentally proved the presence of a new pathway of homoarginine catabolism - its transamination by AGXT2 with formation of GOCA and demonstrated that endogenous AGXT2 is required for maintenance of homoarginine levels in mice. PMID: 27752063
    3. In this work, we describe an assay for the AGXT2 activity in mouse liver and kidney tissue. The overall production rates of DMGV-d(6) in mice were 195.37 pmol/min/mg total protein in liver and 85.21 pmol/min/mg total protein in kidney tissue. PMID: 23280748
    4. Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. PMID: 23023372
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Class-III pyridoxal-phosphate-dependent aminotransferase family
  • 數據庫鏈接：

    KEGG: mmu:268782

    UniGene: Mm.482244