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  4. Recombinant Human Spectrin beta chain, non-erythrocytic 1 (SPTBN1), partial

Recombinant Human Spectrin beta chain, non-erythrocytic 1 (SPTBN1), partial

  • 貨號：
    CSB-YP733819HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 貨號：
    CSB-EP733819HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 貨號：
    CSB-EP733819HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 貨號：
    CSB-BP733819HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 貨號：
    CSB-MP733819HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SPTBN1
  • Uniprot No.：
  • 別名：
    Spectrin beta chain, non-erythrocytic 1; Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1; SPTBN1 SPTB2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 表達區域：
    2197-2307
  • 氨基酸序列
    SAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAIS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
  • 基因功能參考文獻：
    1. c-Met overexpression, HER-2 gene amplification, and SPTBN1-ALK gene fusion can coexist in lung adenocarcinoma and may become a potential biomarker of cancer refractory to crizotinib, chemotherapy, and radiotherapy as well as of a relatively poor prognosis. PMID: 27496196
    2. Subjects whose head and neck tumors expressed spectrin were 4.60 times more likely (hazard ratio; 95% confidence interval: 1.88-11.25) to die at any given time when compared with those without spectrin (P = .001). PMID: 27095047
    3. TGF-beta1 and ELF protein are potential and reliable biomarkers for predicting prognosis in HCC patients after hepatic resection. PMID: 25880619
    4. betaII spectrin is critical for normal myocyte electric activity. Dysfunction in the betaII spectrin-dependent cytoskeleton in cardiomyocytes contributes to human arrhythmia. PMID: 25632041
    5. decreased SPTBN1 and kallistatin gene expression associated with decreased relapse-free survival in hepatocellular carcinoma PMID: 25307947
    6. in human HCC tissues, SPTBN1 expression correlated negatively with expression levels of STAT3, ATF3, and CREB2; SMAD3 expression correlated negatively with STAT3 expression PMID: 25096061
    7. genetic association study in population of 1,012 Han women in China: Data suggest that an SNP in SPTBN1 (rs11898505) is associated with osteoporotic fractures and bone mineral density of lumbar spine in aging women. PMID: 22798246
    8. Results suggest that epigenetic silencing of SPTBN1 (beta2SP) is a new potential causal factor in BWS patients. PMID: 20739274
    9. reduced SPTBN1 expression correlated with shorter survival of pancreatic cancer patients, suggesting a tumor suppressor function of this gene PMID: 20886430
    10. High affinity and slow overall kinetics of association/dissociation of beta II-spectrin may suit it well to a role in strengthening cell junctions and providing stable anchorage for transmembrane proteins at points specified by cell-adhesion molecules. PMID: 12820899
    11. Quantitative analysis of erythrocyte membrane proteins revealed increase in beta-spectrin from patients with homozygous and heterozygous forms of beta-thalassemia. PMID: 15310273
    12. ankyrin-G and beta(2)-spectrin are functional partners in biogenesis of the lateral membrane of epithelial cells PMID: 17074766
    13. because both the T2159E mutant and the wild-type allow neuritogenesis, we conclude that the short C-terminal betaII-spectrin is phosphorylated during this process PMID: 17088250
    14. TGF-beta signaling and Smad adaptor embryonic liver fodrin (ELF) suppress human hepatocarcinogenesis, potentially through cyclin D1 deregulation. PMID: 17546056
    15. E-cadherin thus requires both ankyrin-G and beta-2-spectrin for its cellular localization in early embryos as well as cultured epithelial cells. PMID: 17620337
    16. Our results therefore indicate the importance of N-terminal region for lipid-binding activity of the beta-spectrin ankyrin-binding domain and its substantial role in maintaining the spectrin-based skeleton distribution. PMID: 17716929
    17. Characterization of the 2p21 breakpoint identified the SPTBN1 gene in myeloproliferative disorders. PMID: 18262053
    18. ELF, a TGF-beta adaptor and signaling molecule, functions as a critical adaptor protein in TGF-beta modulation of angiogenesis as well as cell cycle progression. PMID: 18704924

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line.; [Isoform 2]: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Spectrin family
  • 組織特異性：
    Isoform 2 is present in brain, lung and kidney (at protein level).
  • 數據庫鏈接：

    HGNC: 11275

    OMIM: 182790

    KEGG: hsa:6711

    STRING: 9606.ENSP00000349259

    UniGene: Hs.503178



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