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  4. Recombinant Human Regulator of G-protein signaling 1 (RGS1)

Recombinant Human Regulator of G-protein signaling 1 (RGS1)

  • 貨號(hào)：
    CSB-YP019641HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 貨號(hào)：
    CSB-EP019641HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 貨號(hào)：
    CSB-EP019641HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 貨號(hào)：
    CSB-BP019641HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 貨號(hào)：
    CSB-MP019641HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RGS1
  • Uniprot No.：
  • 別名：
    Regulator of G-protein signaling 1; RGS1; B-cell activation protein BL34; Early response protein 1R20; RGS1 1R20 BL34 IER1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full Length
  • 表達(dá)區(qū)域：
    1-209
  • 氨基酸序列
    MRAAAISTPKLDKMPGMFFSANPKELKGTTHSLLDDKMQKRRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
  • 基因功能參考文獻(xiàn)：
    1. Results showed that RGS1 expression was significantly higher in melanoma than that noted in nevus tissue and correlated with reduced diseasespecific survival. Also, RGS1 expression was also found to be related to the proliferation and migration of melanoma cells through regulation of Galphasmediated inactivation of AKT and ERK. PMID: 29620236
    2. The rs12022418 in RGS1 showed novel associations in IgA nephropathy. PMID: 27804980
    3. High RGS1 immunohistochemistry expression associates with poor overall survival in diffuse large B cell lymphoma PMID: 27775850
    4. RGS1 expression may be a prognostic marker for risk stratification and a promising target for the development of a new multiple myeloma therapy. PMID: 27445341
    5. Regulator of G-protein signaling 1 rs2816316 was negatively associated with celiac disease . PMID: 27043536
    6. RGS1 as a potential marker of CRC tissue quality PMID: 26222051
    7. RGS1 suppresses CXCL12-mediated migration and AKT activation in cultured human plasmacytoma cells and plasmablasts. PMID: 25897806
    8. Rgs1 has a role in leukocyte trafficking and vascular inflammation PMID: 25782711
    9. RGS1 and TNFRSF1A polymorphisms tended to be associated with reduced attack severity in Multiple sclerosis. PMID: 24130709
    10. RGS1 is largely upregulated, whereas RGS2 is downregulated in the majority of solid tumors, whereas RGS5 transcripts are greatly increased in eight subtypes of lymphoma with no reports of downregulation in hematological malignancies PMID: 23464602
    11. Markers in the RGS1 gene might be in linkage disequilibrium with a protective allele that reduces the risk of anxiety and depressive disorders. PMID: 23324853
    12. Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines PMID: 21795595
    13. RGS1 is a novel multiple sclerosis susceptibility loci, shared with celieac disease. PMID: 20555355
    14. Overexpression of RGS1 in progenitor pro-B cells (which have little endogenous RGS1) impairs CXCL12-induced focal adhesion kinase activation, chemotaxis, and adhesion to membrane domains. PMID: 15728464
    15. RGS1 and RGS13 act together to regulate chemokine receptor signaling in human germinal center B lymphocytes and contribute significantly to the rapid desensitization of the signaling pathway. PMID: 16565322
    16. RGS1 is (over-) expressed in a broad variety of malignancies PMID: 18301890
    17. Results validate the role of RGS1 as a novel prognostic marker for melanoma given its impact on the survival associated with melanoma. PMID: 18580492
    18. Undifferentiated spondylarthritis (uSpA) peripheral blood mononuclear cells (PBMCs) carry more expressed genes than PBMCs from ankylosing spondylitis (AS) patients. TNFalpha- and IL-17-inducible RGS1 is a biomarker for uSpA, and to a lesser extent for AS. PMID: 19877080

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  • 亞細(xì)胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
  • 組織特異性：
    Detected in peripheral blood monocytes. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9991

    OMIM: 600323

    KEGG: hsa:5996

    STRING: 9606.ENSP00000356429

    UniGene: Hs.75256