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  4. Recombinant Human Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase (ALDH6A1)

Recombinant Human Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase (ALDH6A1)

  • 貨號：
    CSB-YP001578HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 貨號：
    CSB-EP001578HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 貨號：
    CSB-EP001578HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 貨號：
    CSB-BP001578HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 貨號：
    CSB-MP001578HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ALDH6A1
  • Uniprot No.：
  • 別名：
    Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial; MMSDH; EC 1.2.1.27; Aldehyde dehydrogenase family 6 member A1; Malonate-semialdehyde dehydrogenase [acylating]; ALDH6A1 MMSDH
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    34-535
  • 氨基酸序列
    SSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
  • 基因功能參考文獻：
    1. Results show that ALDH6A1 expression is significantly reduced in metastatic prostate cancer and represents a strong marker predicting survival, along with HSP27 and prohibitin. PMID: 30396985
    2. ACAT1, ACACA, ALDH6A1 and MTHFD1 represent novel biomarkers in adipose tissue associated with type 2 diabetes in obese individuals. PMID: 25099943
    3. Mutation analysis in the ALDH6A1 gene can reveal a cause of 3-hydroxyisobutyric aciduria, which may present with only slightly increased urinary levels of 3-hydroxyisobutyric acid, if a patient is metabolically stable [case reports] PMID: 21863277
  • 相關疾病：
    Methylmalonate semialdehyde dehydrogenase deficiency (MMSDHD)
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Aldehyde dehydrogenase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7179

    OMIM: 603178

    KEGG: hsa:4329

    STRING: 9606.ENSP00000450436

    UniGene: Hs.293970