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  4. Recombinant Human Max dimerization protein 1 (MXD1)

Recombinant Human Max dimerization protein 1 (MXD1)

  • 貨號：
    CSB-YP015251HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 貨號：
    CSB-EP015251HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 貨號：
    CSB-EP015251HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 貨號：
    CSB-BP015251HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 貨號：
    CSB-MP015251HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MXD1
  • Uniprot No.：
  • 別名：
    Max dimerization protein 1; Max dimerizer 1; Protein MAD; MXD1 MAD
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 表達區域：
    1-221
  • 氨基酸序列
    MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSSSSVSDSDERGSMQSLGSDEGYSSTSIKRIKLQDSHKACLGL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of a transcriptional repressor complex together with MAX. In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing with MYC for MAX binding. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
  • 基因功能參考文獻：
    1. Results suggest a role for MAX dimerization protein 1 (MXD1) in the control of ribosome biogenesis. PMID: 27588501
    2. Study revealed that HIF-1alpha-induced Mxd1 contributes to cisplatin-resistance in hypoxic osteosarcoma cells by directly repressing PTEN, which leads to the activation of PI3K/AKT antiapoptotic and survival pathway. PMID: 28543796
    3. the miR-382-5p/MXD1 axis plays a critical role in myelopoiesis by affecting the lineage choice of CD34(+) hematopoietic stem/progenitor cells. PMID: 27520398
    4. TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression. PMID: 26698869
    5. down regulation of miR-202 increased the expression of its target Mxd1, followed by Mxd1 recruitment to the Sin3A repressor complex and through its dimerization with Max, and increased repression of Myc-Max target proteins. PMID: 25611699
    6. miR-17-92 cluster members miR-19a/b facilitated gastric cancer cell migration, invasion and metastasis through targeting the antagonist of c-Myc -- MXD1. PMID: 24675462
    7. This study suggests that genetic variants of MXD1 may modulate the effect of smoking on carotid plaque burden. PMID: 24954085
    8. Mad1 gene transfer inhibits the proliferation of human melanoma cells PMID: 12366697
    9. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations PMID: 15235594
    10. MAD1 and Proto-Oncogene Proteins c-myc reciprocally regulate ribosomal DNA transcription, providing a mechanism for coordination of ribosome biogenesis and cell growth PMID: 15282543
    11. c-myc and mad1 can regulate the hTERT transcript in a different manner in hTERT positive cells, but not in normal cells PMID: 15645079
    12. Mad1, Mxi1 and Rox genes were expressed and displayed mutations in haematological malignancies. PMID: 17577784
    13. This study provides a direct link between the growth factor signaling pathways regulated by PI3 kinase/Akt and MAP kinases with Myc-mediated transcription. PMID: 18451027
    14. TGF-beta can override Myc activity despite a stabilizing cancer mutation and induce senescence in myeloid tumor cells, at least in part by induction of Mad1 PMID: 19766114
    15. examination of functionality of basic domains compared with Myc PMID: 12538578
    16. X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. PMID: 12553908
    17. Mad expression and Id2 down-regulation are important events during the TGF-beta cytostatic program in epithelial cells. PMID: 12824180
    18. Max as a novel co-activator of C/EBPalpha functions, thereby suggesting a possible link between C/EBPalpha and Myc-Max-Mad network. PMID: 17082780
    19. The PTEN tumor suppressor gene is a target of MAD1. PMID: 17998413
    20. Mxd1 D112a and Max N78a and H81d, which are located in the leucine zippers of the proteins, can dictate the specificity of heterodimerization and whether or not the Mxd1/Max/DNA complex forms. PMID: 18155722
    21. Results suggest STAT3 functions as a C/EBPbeta cofactor in the regulation of the MAD1 gene. PMID: 18203738
    22. Missense mutations in Mad1, Mxi1 and Rox were found in acute leukemia patients. PMID: 18457265
    23. results suggest that phosphorylation of MAD1 by AKT inhibits MAD1-mediated transcription suppression and subsequently activates the transcription of MAD1 target genes PMID: 19526459

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  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    HGNC: 6761

    OMIM: 600021

    KEGG: hsa:4084

    STRING: 9606.ENSP00000264444

    UniGene: Hs.468908