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  4. Recombinant Human Lutropin subunit beta (LHB)

Recombinant Human Lutropin subunit beta (LHB)

  • 貨號：
    CSB-YP012910HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 貨號：
    CSB-EP012910HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 貨號：
    CSB-EP012910HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 貨號：
    CSB-BP012910HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 貨號：
    CSB-MP012910HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    LHB
  • Uniprot No.：
  • 別名：
    Lutropin subunit beta; Lutropin beta chain; Luteinizing hormone subunit beta; LH-B; LSH-B; LSH-beta; LHB
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    21-141
  • 氨基酸序列
    SREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
  • 基因功能參考文獻：
    1. The rs34349826 and rs6521 loci of the LHB gene were not related to male infertility, which can be further confirmed by larger-sample studies. The GG genotype combination is a protective factor against male infertility. PMID: 30173455
    2. Homozygous nonsense mutation Trp28X in the LHB gene causes LH deficiency. PMID: 29476300
    3. A 20-year-old male from a consanguineous family had pubertal delay, hypogonadism and undetectable LH. A homozygous c.118_120del (p.Lys40del) mutation was identified in the patient and his brother, who subsequently had the same phenotype. PMID: 27656125
    4. In girls with central precocious puberty, increased body mass index (BMI) was associated with slightly lower peak stimulated luteinizing hormone (LH) levels at early pubertal stages (Tanner stages 2 and 3). PMID: 27215137
    5. LHbeta G1052A and LHCGR G935A genes polymorphisms are associated with increased risk of polycystic ovary syndrome in Egyptian women especially in obese cases. PMID: 26662070
    6. The Trp8Arg/Ile15Thr polymorphism within the LHB gene was not associated with endometriosis and infertility. PMID: 25935136
    7. This paper shows a conclusive contribution of Variant-Luteinizing hormone to the natural variance in male serum Luteinizing hormone levels PMID: 25820123
    8. the frequency of v-betaLH in Denmark is similar to a number of European countries PMID: 23725475
    9. LH, progesterone, and TSH can stimulate aldosterone. PMID: 24297486
    10. Data indicate a modulatory effect of luteinizing hormone beta-subunit (LHB) gene polymorphisms on hyperandrogenemia phenotype of Polycystic Ovary Syndrome (PCOS) was observed. PMID: 25111116
    11. No association was found between poor ovarian response to ovarian stimulation and variant-betaLH. PMID: 24625195
    12. Both estradiol and progesterone uniquely modulate basal and GnRH-stimulated gonadotropin promoters without affecting cell growth. PMID: 23160221
    13. FOXO1 transcription factor inhibits luteinizing hormone beta gene expression in pituitary gonadotrope cells PMID: 22865884
    14. Results suggested LH G1052A mutation might influence polycystic ovary syndrome susceptibility and phenotypes. PMID: 22546001
    15. Polymorphisms of Trp8Arg and Ile15Thr in the LH-beta subunit gene occur in infertile women. PMID: 22108961
    16. We identified seven SNPs in the LH beta gene; one SNP in exon 3 (rs#1056917) exhibited significant difference in the allele frequency between the PCOS cases and controls PMID: 22209983
    17. the presence of LHbeta G1502A and ERbeta G+1730A polymorphisms is associated with infertility and endometriosis associated infertility.When two polymorphisms are present it does not appear to increase the chance of developing endometriosis or infertility. PMID: 21764500
    18. Both normal-weight and overweight women with classic PCOS phenotypes present higher LH levels and LH-to-FSH ratios than women with similar BMI but the newer phenotypes. PMID: 21353371
    19. A dileucine determinant in the carboxyl terminal sequence of the luteinizing hormone beta subunit is implicated in the regulated secretion of lutropin PMID: 21458524
    20. Variant LH remains longer in circulation than wild type during GnRH receptor blockade in heterozygous women, in accord with its higher content of sialic acid. PMID: 19890021
    21. relationship between endometriosis and a variant of the beta-subunit of luteinizing hormone PMID: 12042273
    22. findings demonstrate that Gly(102)Ser mutation of the LHbeta gene does not affect receptor binding and bioactivity of the hormone, when tested in vitro PMID: 12356936
    23. Results suggest that a single nucleotide polymorphism alters the post-translational modification of luteinizing hormone beta and hence its structural phenotype. PMID: 12683946
    24. MIP-2A (MBP-1 interacting protein-2A) preferentially expresses in certain tissues, including the pituitary gland, and negatively regulates the LHbeta gene transcription PMID: 12700240
    25. genetically determined variation in LH function might affect susceptibility to prostate cancer via altered testosterone secretion. PMID: 12746844
    26. pituitary exit of LH and FSH occur via different secretion pathways, and are released spatially from the pituitary via different circulatory routes. PMID: 14585810
    27. LH modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition PMID: 14871891
    28. LHbeta-null mice are viable but demonstrate postnatal defects in gonadal growth and function resulting in infertility. PMID: 15569941
    29. The tight linkage between the two missense substitutions in the coding region and the eight nucleotide substitutions in the promoter region of LHB appears to be common to various ethnic groups. PMID: 16410673
    30. homozygous mutation of a 5' splice site in LHB: IVS2+1G-->C disrupts the splicing of messenger RNA, generating a gross abnormality in the processing of the luteinizing hormone beta-subunit mRNA, which abrogates the secretion of luteinizing hormone PMID: 17761593
    31. GnRH stimulation of signaling pathway for annexin A5 mRNA expression is distinct from that of LHbeta mRNA and dependent more on MAPK. PMID: 18703851
    32. Progesterone feedback at the level of the pituitary gonadotrope is likely to play a key role in differential production of the gonadotropin genes. PMID: 19106225
    33. Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. PMID: 19129711
    34. v-betaLH is more frequent in women with ovarian resistance to rhFSH. PMID: 19146763

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  • 相關(guān)疾病：
    Hypogonadotropic hypogonadism 23 without anosmia (HH23)
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Glycoprotein hormones subunit beta family
  • 組織特異性：
    Pituitary gland.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6584

    OMIM: 152780

    KEGG: hsa:3972

    STRING: 9606.ENSP00000221421

    UniGene: Hs.154704



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