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  4. Recombinant Human Interleukin-5 receptor subunit alpha (IL5RA), partial

Recombinant Human Interleukin-5 receptor subunit alpha (IL5RA), partial

  • 貨號：
    CSB-YP011663HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 貨號：
    CSB-EP011663HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 貨號：
    CSB-EP011663HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 貨號：
    CSB-BP011663HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 貨號：
    CSB-MP011663HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Interleukin-5 receptor subunit alpha; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA;CDw125; CD125;IL5RA; IL5R
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 表達區域：
    21-342aa
  • 氨基酸序列
    DLLPDEKISLLPPVNFTIKVTGLAQVLLQWKPNPDQEQRNVNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTILQNDHSLLASSWASAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTEECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPFDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQIEKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGNDEHKPLREW
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    This is the receptor for interleukin-5. The alpha chain binds to IL5.
  • 基因功能參考文獻：
    1. Increased activation of B-cells is present following successful Tuberculosis treatment, and the expression of FASLG and IL5RA could potentially be utilized as a signature to monitor treatment response. PMID: 27682872
    2. Interleukin-5Ralpha-targeted treatments offer promises to patients with eosinophilic respiratory disorders; review PMID: 26859368
    3. This is the first study to show significant associations between IL5RA SNP rs17881144, the ATTAGA haplotype, the GTAGCA haplotype, and the GCTGCA haplotype and eczema. PMID: 25523412
    4. This is the first study to show significant associations between IL5RA SNP rs6771148, the ACTAGA haplotype, and the GTAGCA haplotype and the risk of rhinoconjunctivitis. PMID: 24332579
    5. The MDR analysis showed a potential interaction of C1GALT1-330G/T (rs1008898) and IL5RA31+197A/G (rs340833) on the susceptibility of IgAN (P<0.001). Gene-gene interaction may have some influence on the susceptibility to IgA nephropathy. PMID: 23190752
    6. These findings suggest that a functional polymorphism in IL5RA may contribute to eosinophil and mast cell activation along with specific IgE responses to staphylococcal enterotoxin A in aspirin-exacerbated respiratory disease patients. PMID: 23470716
    7. we determined the structure of IL-5 bound to the extracellular domain of IL-5Ralpha. PMID: 22153509
    8. IL-5Ralpha expression on eosinophils inversely correlated with eosinophilia and was significantly elevated in patients with systemic mastocytosis without eosinophilia PMID: 21762978
    9. Study of engineered deglycosylated IL-5 receptor alpha variant proves that unique carbohydrate groups in multiglycosylated receptors can be utilized asymmetrically for function. PMID: 21770429
    10. Polymorphisms in IL5RA, LPL, ITGA2 and NOS3 genes were independently associated with ischemic stroke in Chinese diabetic population. PMID: 21193198
    11. Increased serum level precedes the development of eczema in children PMID: 20735756
    12. findings indicate that retinoids can differentially regulate expression of IL-5Ralpha and that these effects have functional consequences in vitro on eosinophil and basophil differentiation PMID: 11842302
    13. findings are consistent with an airway tissue-selective expression of the IL-5 receptor that mediates IL-5-induced airway hyperresponsiveness independent of eosinophils PMID: 11897983
    14. expression of membrane IL-5Ralpha on bronchoalveolar lavage eosinophils following airway Ag challenge PMID: 12444154
    15. expression of membrane IL-5 receptor alpha on human eosinophils PMID: 12444155
    16. IL-5 receptor expression in cultured human eosinophils is downregulated by its ligand PMID: 12943658
    17. Our findings suggest that polymorphisms in IL5RA might be among the genetic risk factors for asthma development, especially in atopic populations. PMID: 16217591
    18. These data argue that the charged residues of AF17121 are utilized asymmetrically in the pathway of inhibitor-receptor complex formation to deactivate the receptor function PMID: 16430207
    19. These data establish a critical role for JAK kinases and the Ub/proteasome degradation pathway in IL-5R down-regulation. PMID: 17227823
    20. In chronic eosinophilic leukemia, there was a non-significant association between a SNP at rs4054760 and eosinophil count & IL5RA expression. There was no association with FIP1L1-PDGFRA positivity. PMID: 17914408
    21. The genetic association between CCR3 polymorphisms and the number of circulating eosinophils was revealed;it was more pronounced when the CCR3 polymorphisms were paired with polymorphisms in IL5RA. PMID: 17983872
    22. variants of IL5RA and TNFRSF6B may predispose to sporadic IgA nephropathy PMID: 18256354
    23. IL-5-induced effects on betac assembly in the presence of nontagged IL-5Ralpha provide direct evidence that IL-5 can cause higher order rearrangements of betac homo-oligomers PMID: 18326494
    24. IL-5Rs segregate and traffic into two distinct plasma membrane compartments, and establish that IL-5R endocytosis regulates signaling both positively and negatively. PMID: 18511572
    25. The expression of SOL-IL-5Ralpha and TM-IL-5Ralpha differs according to the eosinophil activation state and localization in the body (blood vs tissue) and may therefore be involved in the fine-tuning of the eosinophil homeostasis. PMID: 19170670
    26. Syntenin forms complexes with multiple IL-5Ralpha chains PMID: 19654410

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 5 subfamily
  • 組織特異性：
    Expressed on eosinophils and basophils.
  • 數據庫鏈接：

    HGNC: 6017

    OMIM: 147851

    KEGG: hsa:3568

    STRING: 9606.ENSP00000256452

    UniGene: Hs.68876



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