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  4. Recombinant Human Guanylin (GUCA2A)

Recombinant Human Guanylin (GUCA2A)

  • 貨號：
    CSB-YP944905HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 貨號：
    CSB-EP944905HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 貨號：
    CSB-EP944905HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 貨號：
    CSB-BP944905HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 貨號：
    CSB-MP944905HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    GUCA2A
  • Uniprot No.：
  • 別名：
    Guanylin; Guanylate cyclase activator 2A; Guanylate cyclase-activating protein 1; Guanylate cyclase-activating protein I; GCAP-I; [Cleaved into: HMW-guanylin; Guanylin] GUCA2A GUCA2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    22-115
  • 氨基酸序列
    VTVQDGNFSFSLESVKKLKDLQEPQEPRVGKLRNFAPIPGEPVVPILCSNPNFPEELKPLCKEPNAQEILQRLEEIAEDPGTCEICAYAACTGC
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
  • 基因功能參考文獻：
    1. Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes. PMID: 29289697
    2. Both guanylin and uroguanylin trigger lipolysis in human visceral adipocytes. Given the lipolytic action of the guanylin system on visceral adipocytes, the herein reported decrease of circulating prouroguanylin concentrations in obese patients may have a role in excessive fat accumulation in obesity. PMID: 27108812
    3. Results demonstrate that GC-C and its ligands, guanylin and uroguanylin are downregulated in ulcerative colitis (UC), and this downregulation is more significant with aggravation of the clinical condition. Therefore, the GC-C signaling pathway may be implicated in the progression of UC. PMID: 27125248
    4. The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines. PMID: 27044258
    5. In summary the structural analysis of missense SNPs is important to decrease the number of potential mutations to be in vitro evaluated for associating them with some genetic diseases PMID: 25899674
    6. There is differential expression of guanylin in colorectal cancer, and the differential expression is associated with tumor stage. PMID: 19742348
    7. The myristoylated wild-type GCAP1 was found to have the highest Ca(2+) affinity and thermal stability. PMID: 20213926
    8. guanylin as a significant marker in salivary gland tumor pathology PMID: 12163390
    9. Results from circular dichroism and NMR spectroscopy validate native and recombinant proguanylin to be well-structured proteins adopting identical secondary structures and three-dimensional folds. PMID: 12463760
    10. hormone prosequence interactions provide an explanation for the negligible bioactivity of the prohormone as well as the important role of the NH2-terminal residues in the disulfide-coupled folding of proguanylin PMID: 12707255
    11. It is likely that gallbladder epithelial cells synthesize and release guanylin into the bile to regulate electrolyte secretion by a paracrine/luminocrine signaling pathway. PMID: 14988827
    12. human cortical collecting duct cells are depolarized by guanylin. PMID: 15780094
    13. Guanylin plays a role in the regulation of ion transport in the colon PMID: 15901896

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Guanylin family
  • 組織特異性：
    Highly expressed in ileum and colon. Found in plasma.
  • 數據庫鏈接：

    HGNC: 4682

    OMIM: 139392

    KEGG: hsa:2980

    STRING: 9606.ENSP00000349493

    UniGene: Hs.778