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  4. Recombinant Human Disks large-associated protein 1 (DLGAP1), partial

Recombinant Human Disks large-associated protein 1 (DLGAP1), partial

  • 中文名稱：
    人DLGAP1重組蛋白
  • 貨號：
    CSB-YP006940HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DLGAP1重組蛋白
  • 貨號：
    CSB-EP006940HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DLGAP1重組蛋白
  • 貨號：
    CSB-EP006940HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DLGAP1重組蛋白
  • 貨號：
    CSB-BP006940HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DLGAP1重組蛋白
  • 貨號：
    CSB-MP006940HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    4933422O14Rik; 9630002F18; AI845682; AI848168; BB075781; D17Bwg0511e; DAP 1 ALPHA; DAP 1; DAP 1 BETA; DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1; Discs large (Drosophila) homolog associated protein 1; Discs large homolog associated protein 1; Disks large associated protein 1; Disks large associated protein 1; alpha isoform; included; Disks large associated protein 1; beta isoform; included; Disks large-associated protein 1; DLGAP 1; Dlgap1; DLGP1_HUMAN; GKAP; GKAP/SAPAP; GKPA/SAPAP; Guanylate kinase associated protein; Guanylate kinase-associated protein; hGKAP; KIAA4162; MGC88156; mKIAA4162; PSD 95/SAP90 binding protein 1; PSD-95/SAP90-binding protein 1; SAP90/PSD 95 associated protein 1; SAP90/PSD-95-associated protein 1; SAPAP 1; SAPAP1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Part of the postsynaptic scaffold in neuronal cells.
  • 基因功能參考文獻：
    1. This study revealed a significant variant (rs12455524) within the gene DLGAP1 for Recurrent major depression. PMID: 26485182
    2. These results strongly suggested involvement of the DLGAP1 gene product in the development of HIV-related lipoatrophy in Thai HIV patients. PMID: 25950743
    3. This study showed that DLGAP1 association with obsessive-compulsive disorder. PMID: 24821223
    4. Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. PMID: 24938595
    5. Results show that the expression and distribution of NMDA receptors subunits GluN1, GluN2A and GluN2B - together with that of postsynaptic protein PSD-95 - are modified in Alzheimer's disease compared to normal aging PMID: 24156266
    6. dlgap1 showed the highest association, of snps examined, with ocd. PMID: 22889921
    7. Study identified six genetic variants, (rs145691437, rs3786431, rs201567254, rs3745051 and rs11662259) and one rare missense mutation (c.1922A>G). SNP- and haplotype-based analyses showed no association of these SNPs with schizophrenia. PMID: 22940546
    8. The GKAP controls the forces operating on microtubules and play a fundamental role in centrosome positioning and cell polarity. PMID: 21041448

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  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
  • 蛋白家族：
    SAPAP family
  • 組織特異性：
    Expressed in brain.
  • 數據庫鏈接：

    HGNC: 2905

    OMIM: 605445

    KEGG: hsa:9229

    STRING: 9606.ENSP00000316377

    UniGene: Hs.594640



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