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  4. Recombinant Human C-type lectin domain family 7 member A (CLEC7A), partial

Recombinant Human C-type lectin domain family 7 member A (CLEC7A), partial

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  • 中文名稱：
    Recombinant Human C-type lectin domain family 7 member A (CLEC7A), partial
  • 品名簡稱：
    Recombinant Human CLEC7A protein, partial
  • 貨號：
    CSB-EP883623HU
  • 說明書：
  • 規(guī)格：
    ￥1536
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 別名：
    Beta-glucan receptor;C-type lectin superfamily member 12;Dendritic cell-associated C-type lectin 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    27.5 kDa
  • 表達區(qū)域：
    66-247aa
  • 氨基酸序列
    TMAIWRSNSGSNTLENGYFLSRNKENHSQPTQSSLEDSVTPTKAVKTTGVLSSPCPPNWIIYEKSCYLFSMSLNSWDGSKRQCWQLGSNLLKIDSSNELGFIVKQVSSQPDNSFWIGLSRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHVSVIYDQLCSVPSYSICEKKFSM
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans.
  • 基因功能參考文獻：
    1. The invertebrate tropomyosin presented in the context of impaired dectin-1 function, as observed in allergic individuals, leads to unrestrained IL-33 secretion and skewing of immune responses toward type 2 immunity. PMID: 29475849
    2. Dectin-1 receptor blockage decreased the IL-12, IL-17, IL-10 and TNF-alpha levels indicating the participation of such receptor in the induction of these cytokines. PMID: 29110339
    3. Dectin-1 is expressed on mDCs and is down-regulated after contact with A. fumigatus, indicating that mDCs recognize A. fumigatus via this receptor. Blocking of Dectin-1, followed by stimulation with depleted zymosan diminished the up-regulation of the T-cell co-stimulatory molecules CD40, CD80, HLA-DR and CCR7 on mDCs and led to decreased release of the cytokines TNF-alpha, IL-8, IL-1beta and IL-10. PMID: 28873980
    4. this study shows that Dectin-1 is essential for IL-1beta production through JNK activation and apoptosis in Aspergillus fumigatus keratitis PMID: 28926773
    5. high tumoral dectin-1 expression was an independent predictor of adverse clinical outcome in ccRCC patients. This molecule and established nomograms might help clinicians in future decision making and therapeutic developments PMID: 27600310
    6. Dectin-1 may have therapeutic implications as a biomarker for metabolic dysregulation in humans. PMID: 28614714
    7. theses data suggest miR-146a may play the potent negative feedback regulator in inflammatory response following Dectin-1 stimulation PMID: 28454101
    8. These results suggest that the intracellular domain, not ligand-binding domain, of Dectin-1 determines the species-specific ligand profile. PMID: 28848046
    9. Unique cytokine secretion and varying expression levels of n Dectin-1 isoforms on monocyte-derived cells may indicate distinct isoform usage as a cell type-specific mechanism of regulating anti-fungal immunity. PMID: 28303575
    10. Dectin 1 is highly expressed on macrophages in pancreatic ductal adenocarcinoma. PMID: 28394331
    11. Dectin-1-mediated activation of the Syk, MAPKs, PI3K and NF-kappaB signaling pathways contributes to F. proliferatum-stimulated CXCL-8 release from BEAS-2B cells and provides an important basis for developing novel therapeutic strategies in clinical allergy. PMID: 28335387
    12. this study shows that curdlan inhibits tumor growth via activating dendritic cells through dectin-1 signaling PMID: 27449326
    13. Dectin-1 is essential for efficient immune response against Mycobacteria. PMID: 26709456
    14. dectin-1 has a role in glycyrrhetinic acid inhibition of contact hypersensitivity induced by trichophytin PMID: 26739065
    15. study represents the first analysis demonstrating that harbouring polymorphisms of Dectin-1 (rs7309123) or TLR2 (rs5743708) represents an independent risk factor of developing IFD in patients with AML undergoing induction chemotherapy. PMID: 26963509
    16. Our data suggest that the genetic diversity of CLEC7A gene influences the autism spectrum disorders (ASD) phenotype by behaving as a disease specifier and imply that the genetic control of innate immune response could determine the ASD phenotype. PMID: 26352598
    17. this study provides novel and opposing functions of hDectin-1 expressed on the two major human DC subsets, pDCs and mDCs PMID: 26123355
    18. The result of this study suggests that there is no correlation between Dectin-1 Y238X Gene polymorphism and RVVC. PMID: 25008994
    19. This study demonstrated that Toll-Like Receptors and Dectin-1, a C-Type Lectin Receptor, Trigger Divergent Functions in CNS Macrophages. PMID: 26156997
    20. Data indicate that Candida albicans beta-Glucan induces high IL-1 receptor antagonist (IL-1Ra) levels, independently from Dectin-1/complement receptor 3 (CR3). PMID: 25461401
    21. The analysis of Dectin-1 gene polymorphisms showed no significant association with fungal keratitis in the northern Han Chinese population. PMID: 25883525
    22. Dectin-1 expressed on human pulmonary epithelial cells has a considerable impact on the Nontypeable Haemophilus influenzae triggered immune response. PMID: 25161190
    23. The superoxide induction with whole glucan particle was concluded to be Dectin-1-mediated and required Src family kinases, phosphatidylinositol-3 kinase and protein kinase B/Akt. PMID: 24440830
    24. IECs may respond to beta-glucans by the secretion of pro-inflammatory chemokines in a Dectin-1- and Syk-dependent pathway PMID: 25251945
    25. The unconventional protein secretion triggered by the dectin-1 pathway is dependent on inflammasome activity and an active autophagic process. PMID: 24808366
    26. Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1. PMID: 24835401
    27. this study investigated the role of dectin-1 expressed by keratinocytes in wound healing PMID: 24721111
    28. dectin-1 expression in conjunctival epithelial cells (CECs) was demonstrated, and expression of both dectin-1 and BAFF in CECs is thought to be involved in pathologic aggravation of allergic inflammatory in patients with vernal keratoconjuctivitis PMID: 24864436
    29. Levels of expression of C-type lectin maybe associated with the pathogenesis of otitis media with effusion. PMID: 24094722
    30. we found that secretory IgA is taken up by M cells via the Dectin-1 receptor, with the possible involvement of Siglec-5 acting as a co-receptor. PMID: 24068891
    31. Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells. PMID: 23745599
    32. Vimentin is an endogenous, activating ligand for Dectin-1. Its presence in areas of artery wall inflammation and O production suggests that vimentin activates Dectin-1 and contributes to lipid oxidation and cholesterol accumulation in atherosclerosis. PMID: 23674515
    33. interaction of Dectin-1 with TLR2 seemed to require that both receptors are from the same species PMID: 23787127
    34. Results suggest that dectin-1 may play a role in the development of nasal polyps, and may participate in the inflammatory reaction in nasal polyps. PMID: 23332664
    35. Expression and function of dectin-1 is defective in monocytes from patients with systemic lupus erythematosus and rheumatoid arthritis. PMID: 23097038
    36. beta-glucan primes the response to components of human microbiota through the dectin-1 and noncanonical Raf-1 kinase pathway. PMID: 23475217
    37. These data demonstrate that MBL has an ability to mediate the opsonophagocytosis of Candida albicans by human neutrophils independent of complement activation, which is coupled with intracellular Dectin-1-triggered ROS production PMID: 23239982
    38. Expressions of TLR2, TLR4 and dectin-1 increased in HaCaT cells in response to Trichophyton rubrum exposure. PMID: 21515468
    39. Antibody constant region peptides can display immunomodulatory activity through activation of the Dectin-1 signalling pathway PMID: 22952831
    40. Dectin-1 contributes to the Aspergillus fumigatus-induced chemokine synthesis in human bronchial epithelial cells. PMID: 22562430
    41. Mycobacterium abscessus activates the NLRP3 inflammasome via dectin-1/Syk-dependent signaling and the cytoplasmic scaffold protein p62/SQSTM1 in human macrophages. PMID: 21876553
    42. Dectin-1 and DC-SIGN polymorphisms are associated with invasive pulmonary Aspergillosis infection PMID: 22384201
    43. identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis PMID: 22674328
    44. dectin-1 acted as an extracellular sensor for pathogens that induced both IL-1beta production and maturation through a noncanonical caspase-8-dependent inflammasome for protective immunity PMID: 22267217
    45. TLR2 and Dectin-1 were expressed by endothelial cells in response to Aspergillus fumigatus stimulation. PMID: 21426724
    46. Yeast-derived beta-glucan lacks cytotoxic effects towards B-lymphoma cells but up-regulation of CD86 suggests maturation of the cells via dectin-1 by the carbohydrate PMID: 22199280
    47. We demonstrate that heterozygosity for the Y238X DECTIN-1 polymorphism in HIV-infected patients predisposes to bacterial infections, and in particular to pneumonia. PMID: 21985303
    48. genetic variation in DECTIN-1 was not associated with susceptibility to candidemia. PMID: 21881131
    49. results define the dectin-1/inflammasome pathway as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by Candida albicans PMID: 21531876
    50. Dectin-1, a pattern recognition receptor involved in antifungal immunity, polymorphisms in the gene may play a role in human disease (Review) PMID: 20700596

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  • 相關疾病：
    Candidiasis, familial, 4 (CANDF4)
  • 亞細胞定位：
    Cell membrane; Single-pass type II membrane protein.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.; [Isoform 7]: Cytoplasm.
  • 組織特異性：
    Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14558

    OMIM: 606264

    KEGG: hsa:64581

    STRING: 9606.ENSP00000302569

    UniGene: Hs.143929