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  4. Recombinant Human C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3), partial

Recombinant Human C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3), partial

  • 中文名稱：
    人MAPK8IP3重組蛋白
  • 貨號：
    CSB-YP891573HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MAPK8IP3重組蛋白
  • 貨號：
    CSB-EP891573HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MAPK8IP3重組蛋白
  • 貨號：
    CSB-EP891573HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MAPK8IP3重組蛋白
  • 貨號：
    CSB-BP891573HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MAPK8IP3重組蛋白
  • 貨號：
    CSB-MP891573HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    C-jun-amino-terminal kinase-interacting protein 3; FLJ00027; Homolog of Drosophila Sunday driver 2; JIP-3; JIP3; JIP3_HUMAN; JNK / Stress Activated Protein Kinase Associated Protein 1; JNK Interacting Protein 3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK associated protein 1; JSAP1; KIAA1066; MAPK8IP3; Mitogen Activated Protein kinase 8 Interacting Protein 3; Mitogen-activated protein kinase 8-interacting protein 3; Syd; SYD2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development. Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation.
  • 基因功能參考文獻：
    1. JIP3 was highly expressed in hearts with hypertrophic cardiomyopathy. The findings indicated that blockage of JIP3 could alleviate cardiac hypertrophy via inactivating JNK pathway, and thus might be a promising strategy to prevent pathological cardiac hypertrophy. PMID: 29604277
    2. The crystal structure of an N-terminally truncated form of LZII of JIP3 alone shows an unexpected antiparallel arrangement. PMID: 26919523
    3. Results demonstrated the increased expression of JIP3 in the temporal neocortex of TLE patients and in the experimental model of epileptic seizures PMID: 26002316
    4. JSAP1 and JLP play critical roles in kinesin-1-dependent axonal transport PMID: 26320416
    5. The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions PMID: 22072677
    6. This study demonistrated that JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1. PMID: 21775604
    7. Expression of constitutively active PI3K stimulated translocation of Tiam1 to the membrane, increased Rac1 activity, and increased wound healing of airway epithelial cells. Increased Rac1 activity resulted in increased phosphorylation of JNK1. PMID: 20018857
    8. demonstration that JSAP1 bound ASK1 and enhanced ASK1- and H2O2-induced JNK activity PMID: 12189133
    9. Pressure application of 160 mmHg for 3 h produced cell proliferation and activated ERK and c-JUN N-terminal kinase PMID: 15532711
    10. JIP1 and JIP3, have a cross-talk that leads to the regulation of the ASK1-SEK1-JNK signal during glucose deprivation; cross-talk between JIP3 and JIP1 is mediated through SEK1-JNK2 and Akt1. PMID: 15911620
    11. JSAP1.FAK complex functions cooperatively as a scaffold for the JNK signaling pathway and regulator of cell migration on FN PMID: 16141199
    12. Upon UVB-induced stress in keratinocytes, ROCK1 was activated, bound to JIP-3, and activated the JNK pathway PMID: 19036714
    13. Cyclic mechanical strain impairs signaling of cell migration after injury via a pathway that involves FAK-JIP3-JNK. PMID: 19574423

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  • 亞細胞定位：
    Cytoplasm. Golgi apparatus. Cytoplasmic vesicle. Cell projection, growth cone. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region.
  • 蛋白家族：
    JIP scaffold family
  • 數據庫鏈接：

    HGNC: 6884

    OMIM: 605431

    KEGG: hsa:23162

    STRING: 9606.ENSP00000250894

    UniGene: Hs.207763



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