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  4. Recombinant Human Band 4.1-like protein 3 (EPB41L3), partial

Recombinant Human Band 4.1-like protein 3 (EPB41L3), partial

  • 貨號：
    CSB-YP2280HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 貨號：
    CSB-EP2280HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 貨號：
    CSB-EP2280HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 貨號：
    CSB-BP2280HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 貨號：
    CSB-MP2280HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Band 4.1-like protein 3; 4.1B; Differentially expressed in adenocarcinoma of the lung protein 1; DAL-1; Erythrocyte membrane protein band 4.1-like 3; [Cleaved into: Band 4.1-like protein 3, N-terminally processed] EPB41L3 DAL1 KIAA0987
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 表達區域：
    110-391
  • 氨基酸序列
    MQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.
  • 基因功能參考文獻：
    1. We revealed that DAL-1 was downregulated while HSPA5 was upregulated in NSCLC and found the protein of DAL-1 and HSPA5 co-localized in the cytoplasm and nucleus. We demonstrated that DAL-1 can suppress the expression of HSPA5 on mRNA and protein levels, and decrease EMT, migration, invasion and proliferation abilities by down-regulating HSPA5 PMID: 29048640
    2. 4.1B gene deletion was sufficient to transform SV40T antigen-immortalized mouse embryonic fibroblasts (iMEFs), as reflected by the ability of 4.1B(-/-) iMEFs to growth in the environments that were growth restrictive for 4.1B(+/+) iMEFs and to form tumors in nude mice, whereas 4.1B(+/+) iMEFs were unable to form tumors in vivo. PMID: 27312663
    3. aberrant expression of DAL-1 by hypermethylation in the promoter region results in tumor suppressor gene behavior that plays important roles in the malignancy of gastric cancers PMID: 26923709
    4. findings reveal that EPB41L3 suppresses tumour cell invasion and inhibits MMP2 and MMP9 expression in esophageal squamous cell carcinoma cells PMID: 26916087
    5. Downregulation of DAL-1/4.1B expression effectively suppresses DAL-1/4.1B protein expression in lung cancer cells. PMID: 26300315
    6. a central role of CADM1 in stabilizing the complex with 4.1B and MPP3 PMID: 25780926
    7. We conclude that EPB41L3, RASSF2 and TSP-1 genes are involved in the pathogenesis of diffuse gliomas PMID: 25621889
    8. Our study demonstrates for the first time that platelet-secreted miR-223 via P-MVs can promote lung cancer cell invasion via targeting tumor suppressor EPB41L3. PMID: 25881295
    9. The results suggest that tumor suppressor DAL-1 could also attenuate epithelial-to mesenchymal transition and be important for tumor metastasis in the early transformation process in lung cancer. PMID: 25609022
    10. In granulosa cells, there are significant changes in expression during follicular maturation. PMID: 24828608
    11. Studies indicate that tumor suppressor protein 4.1B/DAL-1 plays a crucial regulatory role in cell growth and differentiation. PMID: 25183197
    12. aberrant CADM1 and 4.1B expression is involved in progression of breast cancer, especially in invasion into the stroma and metastasis PMID: 21526423
    13. Loss of expression of the differentially expressed in adenocarcinoma of the lung protein is associated with metastasis of non-small cell lung carcinoma. PMID: 22782504
    14. Data suggest that the four-gene methylation panel might provide an alternative triage test after primary high-risk papillomavirus (hr-HPV) testing. PMID: 21796628
    15. miR-223, induced by the transcription factor Twist, posttranscriptionally downregulates EPB41L3 expression by directly targeting its 3'-untranslated regions. PMID: 21628394
    16. Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B). PMID: 21131357
    17. The expressions of TSLC1 and 4.1B in non-small cell lung cancer tissues were significantly lower than that in adjacent lung tissues. PMID: 21081044
    18. An inducible model of EPB41L3 expression in three-dimensional spheroids confirmed that reexpression of EPB41L3 induces extensive apoptotic cell death in ovarian cancers. PMID: 20651987
    19. Results identify erythrocyte protein band 4.1-like 3 (protein 4.1B) as an intracellular effector molecule of Synaptic Cell Adhesion Molecule 1 (SynCAM1) that is sufficient to recruit NMDA-type receptors (NMDARs) to SynCAM1 adhesion sites in COS7 cells. PMID: 19796685
    20. Results show that three 14-3-3 isoforms, beta, gamma and eta, are DAL-1/Protein 4.1B-binding proteins. PMID: 11996670
    21. DAL-1 protein functions at the interface between cell adhesion and apoptosis in suppressing breast cancer cell growth PMID: 12115567
    22. TSLC1 and DAL-1, two distinct tumor suppressor proteins, directly associate in lung cancer. PMID: 12234973
    23. DAL-1 has a role in the development of multiple meningioma and does not function as a tumor suppressor PMID: 12478663
    24. Mechanisms such as genetic imprinting and monoallelic expression in combination with los os heterozygosity may be responsible for loss of EPB41L3 protein in early breast tumors. PMID: 15138999
    25. protein 4.1B in mouse small intestine & DAL-1 in human colon showed similar distributions in normal intestinal epithelial cells; expression reduced in intestinal carcinoma; may function in preventing malignant transformation of intestinal epithelial cells PMID: 15517334
    26. U2 domain, when properly targeted to the plasma membrane, contains all the residues necessary for mediating Protein 4.1B growth suppression. PMID: 15688033
    27. 4.1B gene deletion was statistically more common in ependymomas. PMID: 15731777
    28. DAL-1 methylation is involved in the development and progression of non-small cell lung cancers and provides an indicator for poor prognosis. PMID: 15837747
    29. The low mutational frequency in the study discounts sequence variations in DAL-1/4.1B as the main mechanism underlying participation of this gene in the neoplastic transformation of meningiomas. PMID: 16142420
    30. promoter methylation of the 4.1B is one of the most frequent epigenetic alterations in RCCC and could predict the metastatic recurrence of the surgically resected RCCC PMID: 16152585
    31. methylation of DAL-1 leading to loss of the expression, is an important event in the pathogenesis of non-small-cell lung cancer PMID: 16205641
    32. These studies implicate the DAL-1/4.1B locus in sporadic meningiomas less commonly than reported previously, and suggest that it is a progression rather than an initiation locus. PMID: 16213361
    33. These results suggest that protein methylation cooperates with DAL-1/4.1B-associated caspase 8-specific activation to induce apoptosis in breast cancer cells. PMID: 16420693
    34. TSLC1 and DAL-1 are involved in the pathogenesis of breast cancer and are frequently inactivated by methylation PMID: 17260099
    35. suggest a more general role for Protein 4.1B as a negative regulator of cancer progression to metastatic disease PMID: 17640904
    36. A growing body of evidence supports a role for loss of EPB41L3 in tumor progression, including in prostate cancer [review] PMID: 18554153
    37. Our results demonstrate a frequent, predominant epigenetic silencing of CADM1 and DAL-1 in nasal NK/T-cell lymphoma (NL), which likely play a synergic role in NL pathogenesis. PMID: 19115211
    38. Identify Golgi-specific protein 4.1 that appears to have an essential role in maintaining the structure of the Golgi and in assembly of a subset of membrane proteins. PMID: 19299464

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Detected in the cytoplasm of actively dividing cells.
  • 組織特異性：
    Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung.
  • 數據庫鏈接：

    HGNC: 3380

    OMIM: 605331

    KEGG: hsa:23136

    STRING: 9606.ENSP00000341138

    UniGene: Hs.213394