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Recombinant Human [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (BCKDK)

  • 中文名稱:
    Recombinant Human [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(BCKDK)
  • 貨號:
    CSB-YP002607HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(BCKDK)
  • 貨號:
    CSB-EP002607HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(BCKDK)
  • 貨號:
    CSB-EP002607HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(BCKDK)
  • 貨號:
    CSB-BP002607HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial(BCKDK)
  • 貨號:
    CSB-MP002607HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    [3 methyl 2 oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial ; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase; BCKD kinase ; BCKD-kinase; BCKD_HUMAN; BCKDHKIN; Bckdk; BCKDKD; BDK; Branched chain alpha keto acid dehydrogenase kinase; Branched chain ketoacid dehydrogenase kinase; Branched-chain alpha-ketoacid dehydrogenase kinase; mitochondrial
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    31-412
  • 氨基酸序列
    STSATDTHHV EMARERSKTV TSFYNQSAID AAAEKPSVRL TPTMMLYAGR SQDGSHLLKS ARYLQQELPV RIAHRIKGFR CLPFIIGCNP TILHVHELYI RAFQKLTDFP PIKDQADEAQ YCQLVRQLLD DHKDVVTLLA EGLRESRKHI EDEKLVRYFL DKTLTSRLGI RMLATHHLAL HEDKPDFVGI ICTRLSPKKI IEKWVDFARR LCEHKYGNAP RVRINGHVAA RFPFIPMPLD YILPELLKNA MRATMESHLD TPYNVPDVVI TIANNDVDLI IRISDRGGGI AHKDLDRVMD YHFTTAEAST QDPRISPLFG HLDMHSGAQS GPMHGFGFGL PTSRAYAEYL GGSLQLQSLQ GIGTDVYLRL RHIDGREESF RI
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
  • 基因功能參考文獻:
    1. our study indicates that BCKDK promotes colorectal tumorigenesis through up-regulation of the MAPK signaling pathway by phosphorylating MEK at Ser221. PMID: 28501528
    2. There is a relationship between plamsa CST and BCKDK in sepsis patients. PMID: 27773658
    3. Results demonstrate that BCKDK mutations can result in neurobehavioral deficits in humans. PMID: 24449431
    4. This publication is about the mouse gene but contains the 5' sequence of the human gene, including upstream open reading frame information. PMID: 15302860
    5. employment of multidimensional heteronuclear NMR techniques to determine the structure and dynamics of the LBD of the human branched-chain alpha-keto acid dehydrogenase complex (hbLBD) PMID: 11839747

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  • 相關疾病:
    Branched-chain ketoacid dehydrogenase kinase deficiency (BCKDKD)
  • 亞細胞定位:
    Mitochondrion matrix. Mitochondrion.
  • 蛋白家族:
    PDK/BCKDK protein kinase family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 16902

    OMIM: 614901

    KEGG: hsa:10295

    STRING: 9606.ENSP00000219794

    UniGene: Hs.513520



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