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  4. Recombinant Drosophila melanogaster Spectrin alpha chain (alpha-Spec), partial

Recombinant Drosophila melanogaster Spectrin alpha chain (alpha-Spec), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster Spectrin alpha chain(alpha-Spec) ,partial
  • 貨號：
    CSB-YP022632DLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Spectrin alpha chain(alpha-Spec) ,partial
  • 貨號：
    CSB-EP022632DLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Spectrin alpha chain(alpha-Spec) ,partial
  • 貨號：
    CSB-EP022632DLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Spectrin alpha chain(alpha-Spec) ,partial
  • 貨號：
    CSB-BP022632DLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Spectrin alpha chain(alpha-Spec) ,partial
  • 貨號：
    CSB-MP022632DLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    alpha-Spec
  • Uniprot No.：
  • 別名：
    alpha-Spec; SPEC-A; CG1977; Spectrin alpha chain
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization.
  • 基因功能參考文獻：
    1. a functional spectrin-integrin complex is important for regulation of the actomyosin cytoskeleton and tissue architecture PMID: 26952981
    2. Alpha-pectrin regulates Hippo signaling by modulating cytoskeletal actomyosin activity. PMID: 25826608
    3. Our data provide the first rigorous test for the general requirement for tetramer-based non-erythroid spectrin networks throughout an organism and find that they have very limited roles, in direct contrast to the current paradigm PMID: 25381248
    4. The well-characterized interaction between AE1 and the spectrin cytoskeleton in erythrocytes is not conserved in Drosophila. PMID: 20573195
    5. Specific regions of the spectrin molecule were tested for a role in polarized assembly and function. PMID: 18287096
    6. Molecular mechanisms that enhance synaptic stability despite persistent disruption of the spectrin/Ank/microtubule cytoskeleton are reported. PMID: 19805631

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Golgi apparatus. Note=Near the inner surface of the plasma membrane of nearly all cells. Lva-alpha-spectrin complexes are found at the Golgi.
  • 蛋白家族：
    Spectrin family
  • 組織特異性：
    A substantial pool of maternal protein in the egg undergoes dynamic changes in distribution early in embryogenesis. In gastrulated embryo, the highest level of protein is found in the respiratory tract cells and the lowest in parts of the forming gut.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG1977

    STRING: 7227.FBpp0305100

    UniGene: Dm.7397