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  4. Recombinant BRCA1-associated RING domain protein 1 (brd-1), partial

Recombinant BRCA1-associated RING domain protein 1 (brd-1), partial

  • 中文名稱：
    Recombinant BRCA1-associated RING domain protein 1(brd-1) ,partial
  • 貨號：
    CSB-YP630333CXY
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant BRCA1-associated RING domain protein 1(brd-1) ,partial
  • 貨號：
    CSB-EP630333CXY
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant BRCA1-associated RING domain protein 1(brd-1) ,partial
  • 貨號：
    CSB-EP630333CXY-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant BRCA1-associated RING domain protein 1(brd-1) ,partial
  • 貨號：
    CSB-BP630333CXY
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant BRCA1-associated RING domain protein 1(brd-1) ,partial
  • 貨號：
    CSB-MP630333CXY
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    brd-1
  • Uniprot No.：
  • 別名：
    brd-1; K04C2.4BRCA1-associated RING domain protein 1; BARD1; Ce-BRD-1; Cebrd-1; EC 2.3.2.27; RING-type E3 ubiquitin transferase BARD1
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity. When bound to chromatin, the brc-1-brd-1 heterodimer within the CeBCD complex is inactive during normal conditions, but in response to DNA damage, the brc-1-brd-1 heterodimer associates with other proteins such as the recombinase rad-51 or the E2-ubiquitin-conjugating enzyme let-70, which activate the CeBCD complex as an E3-ubiquitin ligase. Moreover, association between the brc-1-brd-1 heterodimer and rad-51 and let-70, probably requires DNA checkpoint proteins such as atl-1 and mre-11 in order to induce ubiquitination at DNA damage sites. To this end, the brc-1-brd-1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by ionizing radiation for example. In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand break repair to ensure sister chromatid recombination and aid chromosome stability.
  • 亞細胞定位：
    Cytoplasm. Nucleus. Chromosome.
  • 數據庫鏈接：

    KEGG: cel:CELE_K04C2.4

    STRING: 6239.K04C2.4.3

    UniGene: Cel.5319