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  4. ZNF217 Recombinant Monoclonal Antibody

ZNF217 Recombinant Monoclonal Antibody

  • 中文名稱：
    ZNF217 Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA074893A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Zinc finger protein 217 expression in HAP-1 cells using Zinc finger protein 217 antibody. Green, isotype control; red, Zinc finger protein 217.
    • Immunocytochemical staining of HAP-1 cells with zinc finger protein 217 antibody. Nuclei were stained blue with DAPI; Zinc finger protein 217 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
    • Western blotting analysis using zinc finger protein 217 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with zinc finger protein 217 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ZNF217
  • 別名：
    ZNF217; Zinc Finger Protein 217; ZABC1
  • 反應(yīng)種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human ZNF217 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    10D10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.
  • 基因功能參考文獻(xiàn)：
    1. this study underscored that elevated expression of ZNF217 promotes prostate cancer growth by restraining ferroportin -conducted iron egress PMID: 27768596
    2. this paper shows that hypoxia-inducible factors regulate pluripotency factor expression by ZNF217-mediated modulation of RNA methylation in breast cancer cells PMID: 27590511
    3. ZNF217 overexpression is associated with neoplasms. PMID: 27007163
    4. GATA3-driven expression of miR-503 inhibits prostate cancer progression by repressing ZNF217 expression. PMID: 27267060
    5. ZNF217 regulates N6-methyladenosine mRNA deposition in embryonic stem cells thus contributing to tumorigenesis by dysregulating gene expression programs. PMID: 27519282
    6. The report shows that the ZNF217 oncogene is a crucial mediator and indicator of bone metastasis from breast cancer. PMID: 28207159
    7. findings indicate that lncRNA-ATB governs the autocrine secretion of TGF-beta2 in KFs, at least in part, by downregulating the expression level of ZNF217 via miR-200c, suggesting a signaling axis consisting of lncRNA-ATB/miR-200c/ZNF217/TGF-beta2 PMID: 27090737
    8. Review: highlight the downstream molecular targets and signaling pathways of ZNF217 in tumor cells. PMID: 26431164
    9. High expression of ZNF217 is associated with enhanced cell migration and invasion in colorectal carcinoma. PMID: 25824781
    10. Two polymorphisms in ZNF217 in Mexican patients with colorectal cancer, were studied. PMID: 25729968
    11. ZNF217 has an oncogenic role in colorectal cancer and is regulated by miR-203. PMID: 25621839
    12. we conclude that ZNF217 may contribute to ovarian cancer invasion and metastasis, and associated with worse clinical outcomes. PMID: 25031722
    13. Synergic effects of loss of ARID1A and PI3K-Akt pathway activation as well as ZNF217 amplification may be related to the development of ovarian clear cell carcinoma. PMID: 24336158
    14. ERalpha expression highly correlates with ZNF217 in lysates from breast tumors. PMID: 24962896
    15. ZNF217 expression seems to be a novel prognostic biomarker in gastric cancer. PMID: 25202062
    16. Study investigated nested regulatory circuits of miR-200c/ZEB1 and miR-200c/ZNF217/TGF-beta/ZEB1 in synergistically promoting trastuzumab resistance and metastasis of breast cancer cells. PMID: 24615544
    17. New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. PMID: 23436653
    18. downregulation of miR-24ZNF17 in prostate cancer (PCa) corresponds to an upregulation of ZNF217; ZNF217 could be identified as an oncogene because it is overexpressed in prostate cancer (PCa) and affects the growth of PCa cell lines PMID: 22815235
    19. Data suggest that the transcription factor ZNF217 is a biomarker of poor prognosis and a therapeutic target in patients with breast cancer. PMID: 22728437
    20. study showed that high levels of expression of ZNF217 mRNA are associated with poor prognosis and the development of metastases in breast cancer; ZNF217 also promoted epithelial-mesenchymal transition (EMT) in mammary epithelial cells PMID: 22593193
    21. found ZNF217 gene amplification to be significantly correlated with lymph node metastasis (p<0.05) in ovarian clear cell carcinoma. Profound inhibition of cell migration and invasion was observed in siRNA-treated cells with ZNF217 amplification PMID: 22843878
    22. These findings indicate that ZNF217 overexpression is critical to growth and survival of OCCCs with ZNF217 gene amplification. PMID: 22139760
    23. multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain PMID: 21908891
    24. ZNF217 is overexpressed in GBMs and contributes to the maintenance of GSCs, which is regulated by HIFs released by the hypoxic environment of the tumor PMID: 21483406
    25. Data suggest that ZNF217 might play an important role in breast neoplastic progression and chemoresistance, and that Aurora-A might be involved in ZNF217-mediated effects. PMID: 21059223
    26. results show that ZNF217 regulates ErbB3 expression PMID: 20661224
    27. ZNF217 amplification was associated with medullary breast cancer. PMID: 20429623
    28. ZNF217 can be an important candidate gene responsible for the occurrence and progression of ovarian carcinomas. PMID: 19403395
    29. c-MYC amplification is an early event in breast cancer progression, while ZNF217 and Her2/neu amplification may play a role in the later stage of tumor development PMID: 15756435
    30. ZNF217 may promote neoplastic transformation by increasing cell survival during telomeric crisis and may promote later stages of malignancy by increasing cell survival during chemotherapy. PMID: 16203743
    31. These results identify a new CtBP interaction motif and establish ZNF217 as a transcriptional repressor protein that functions, at least in part, by associating with CtBP. PMID: 16940172
    32. implicate ZNF217 and its associated proteins in a novel pathway that may have profound effects on cancer progression PMID: 17130829
    33. ZNF217 and its associated pathways may provide new targets for therapeutic intervention in human cancers.[REVIEW] PMID: 17572303
    34. Suggest that ZNF217 might play a crucial role in the proliferation and invasion of ovarian cancer. PMID: 18425333
    35. These results establish the ZNF217 complex as a novel negative regulator of the p15(ink4b) gene and may constitute an important link between amplification of ZNF217 and the loss of TGF-beta responsiveness in breast cancer. PMID: 18625718
    36. ZNF217 assembles a distinct set of histone modifying proteins at target DNA sites that act synergistically in transcriptional repression. PMID: 19242095

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13009

    OMIM: 602967

    KEGG: hsa:7764

    STRING: 9606.ENSP00000304308

    UniGene: Hs.155040