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  4. USP39 Recombinant Monoclonal Antibody

USP39 Recombinant Monoclonal Antibody

  • 中文名稱：
    USP39 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA066954A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of USP39 expression in HepG2 cells using USP39 antibody. Green, isotype control; red, USP39.
    • Immunocytochemical staining of HepG2 cells with USP39 antibody. Nuclei were stained blue with DAPI; USP39 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar, 20 μm.
    • Western blotting analysis using USP39 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with USP39 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    USP39; Ubiquitin Specific Peptidase 39; SNRNP65; CGI-21; SAD1; Small Nuclear Ribonucleoprotein 65kDa (U4/U6.U5); U4/U6.U5 Tri-SnRNP-Associated 65 KDa Protein; Ubiquitin Carboxyl-Terminal Hydrolase 39; Ubiquitin Specific Protease 39; SAD1 Homolog; SnRNP Assembly Defective 1 Homolog (S. Cerevisiae); Inactive Ubiquitin-Specific Peptidase 39; U4/U6.U5 Tri-SnRNP-Associated Protein; SnRNP Assembly Defective 1 Homolog; EC 3.4.19.12 ;HSPC332; 65K
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human USP39 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    8F1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity.
  • 基因功能參考文獻：
    1. The above findings suggest that USP39 plays a vital oncogenic role in the tumorigenesis of prostate cancer PMID: 26959883
    2. Knockdown of USP39 expression in osteosarcoma cell line U2OS cell significantly decreased cell proliferation, impaired colony formation ability. A further analysis indicated suppression of USP39 arrested cell cycle progression at G2/M phase via p21 dependent way. In addition, the results of Annexin V/7-AAD staining suggested the knockdown of USP39 could promote U2OS cell apoptosis through PARP cleavage. PMID: 28403900
    3. Data suggest that ZIP, USP39, Prp24/p100/SART3, and Prp43 associate to form complex instrumental in spliceosome assembly; ZIP regulates pre-mRNA splicing of USP39 independent of RNA binding; stable 35S tri-snRNP particles are enriched in Cajal body. (ZIP = zinc finger and G-patch domain-containing protein; SART3 = squamous cell carcinoma antigen recognised by T cells 3; Prp43 = RNA helicase Prp43) PMID: 28878014
    4. High USP39 expression is associated with colon and lung cancer. PMID: 28154181
    5. Data show that knockdown of ubiquitin specific peptidase 39 (USP39), a direct target of microRNA microRNA-133a, induced cell apoptosis through inhibition of proto-oncogene proteins c-akt (AKT) signaling pathway in pancreatic cancer (PC) cells. PMID: 28286270
    6. Results show a significantly higher expression of USP39 in colorectal cancer tissues and cell lines and provide evidence that USP39 protein plays an important role in the growth and metastasis of colorectal cancer mainly through Wnt/beta-catenin pathway. PMID: 28259917
    7. shRNA-mediated knockdown of USP39 inhibited the growth and colony formation ability of GC cells. suppression of USP39 induced G2/M-phase arrest and increased the cleavage of PARP (Asp214). PMID: 27175747
    8. USP39 is upregulated in melanoma tissues and that it is implicated in melanoma progression by regulating cell cycle and apoptosis via ERK1/2 signal pathways. PMID: 27456357
    9. study indicates that USP39 may be functionally involved in lung cancer growth and act as a potential molecular target for human lung cancer diagnosis and treatment. PMID: 27629785
    10. Our data indicate that USP39 knockdown inhibited the growth of HCC both in vitro and in vivo through G2/M arrest, which was partly achieved via the inhibition of FoxM1 splicing. PMID: 26081192
    11. Inducible knockdown of USP39 or overexpression of USP39 in TNBC cells. PMID: 25812575
    12. These results suggest that USP39 may act as an oncogenic factor in breast cancer and could be a potential molecular target for breast cancer gene therapy. PMID: 24126978
    13. These observations suggest Usp39 to be involved in splicing of Aurora B and other mRNAs that are essential for proper spindle checkpoint function. PMID: 18728397

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Peptidase C19 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20071

    OMIM: 611594

    KEGG: hsa:10713

    STRING: 9606.ENSP00000312981

    UniGene: Hs.654745