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  4. TXNDC12 Recombinant Monoclonal Antibody

TXNDC12 Recombinant Monoclonal Antibody

  • 中文名稱：
    TXNDC12 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA995859A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate(30μg), HT-29 whole cell lysate(30μg), HEK293 whole cell lysate(30μg), U-251MG whole cell lysate(30μg), SH-SY5Y whole cell lysate(30μg), K562 whole cell lysate(30μg), Rat liver tissue lysate(30μg)
      All lanes:TXNDC12 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 19 kDa
      Observed band size: 19 kDa
      Exposure time：3min
    • IHC image of CSB-RA995859A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing HepG2 cells stained with CSB-RA995859A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10, 000 events was performed.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    TXNDC12
  • 別名：
    AG1 antibody; AGR1 antibody; anterior gradient homolog 1 antibody; endoplasmic reticulum protein ERp19 antibody; Endoplasmic reticulum resident protein 18 antibody; Endoplasmic reticulum resident protein 19 antibody; endoplasmic reticulum thioredoxin superfamily member, 18 kDa antibody; ER protein 18 antibody; ER protein 19 antibody; ERP 18 antibody; ERP16 antibody; ERp18 antibody; ERp19 antibody; hAG 1 antibody; hAG1 antibody; hTLP19 antibody; PDIA16 antibody; protein disulfide isomerase family A, member 16 antibody; thioredoxin domain containing 12 (endoplasmic reticulum antibody; Thioredoxin domain-containing protein 12 antibody; thioredoxin like protein p19 antibody; Thioredoxin-like protein p19 antibody; TLP19 antibody; TXD12_HUMAN antibody; TXNDC12 antibody
  • 反應(yīng)種屬：
    Human, Rat
  • 免疫原：
    A synthesized peptide from human TXNDC12 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    21A7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Possesses significant protein thiol-disulfide oxidase activity.
  • 基因功能參考文獻：
    1. We conclude that ERp19 contributes to tumorigenicity and metastasis of gastric cancer PMID: 25940440
    2. ERp18 shows specificity towards a component of the complement cascade, pentraxin-related protein PTX3. PMID: 19887585
    3. putative physiological role for endoplasmic reticulum thioredoxin superfamily member p18(ERp18) in native disulfide bond formation is discussed PMID: 12761212
    4. ERp16 mediates disulfide bond formation in the ER and plays an important role in cellular defense against prolonged ER stress PMID: 18628206
    5. the solution structure of oxidized ERp18 as determined using NMR spectroscopy PMID: 19361226

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  • 亞細胞定位：
    Endoplasmic reticulum lumen.
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24626

    OMIM: 609448

    KEGG: hsa:51060

    STRING: 9606.ENSP00000360688

    UniGene: Hs.476033