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TOE1 Recombinant Monoclonal Antibody

  • 中文名稱:
    TOE1 Recombinant Monoclonal Antibody
  • 貨號:
    CSB-RA246710A0HU
  • 規格:
    ¥1320
  • 圖片:
    • Flow cytometric analysis of TOE1 expression in C2C12 cells using TOE1 antibody. Green, isotype control; red, TOE1.
    • Immunocytochemical staining of C2C12 cells with TOE1 antibody. Nuclei were stained blue with DAPI; TOE1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and Smart Gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using TOE1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with TOE1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TOE1
  • 別名:
    TOE1; Target Of EGR1, Exonuclease; HCaf1z; TOE-1; Target Of EGR1, Member 1 (Nuclear); Target Of EGR1 Protein 1; PCH7
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human TOE1 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    7G9
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, FC, ICC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing.
  • 基因功能參考文獻:
    1. Human cells with reduced levels of TOE1 accumulated 3'-end-extended pre-snRNA. PMID: 28092684
    2. Antiviral potency of TOE1 and its cell-penetrating capability have been identified to lie within a 35-amino-acid region containing the nuclear localization sequence PMID: 26056259
    3. TOE1 has a role in the growth inhibitory activity of Egr1 PMID: 12562764
  • 相關疾?。?/div>
    Pontocerebellar hypoplasia 7 (PCH7)
  • 亞細胞定位:
    Nucleus, nucleolus. Nucleus speckle. Note=Localizes to nuclear speckles.
  • 蛋白家族:
    CAF1 family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 15954

    OMIM: 613931

    KEGG: hsa:114034

    STRING: 9606.ENSP00000361162

    UniGene: Hs.525091