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  4. TCP Recombinant Monoclonal Antibody

TCP Recombinant Monoclonal Antibody

  • 中文名稱：
    TCP Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA256943A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of TCP1 expression in HepG2 cells using TCP1 antibody. Green, isotype control; red, TCP1.
    • Immunocytochemical staining of HepG2 cells with TCP1 antibody. Nuclei were stained blue with DAPI; TCP1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using TCP1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with TCP1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TCP
  • 別名：
    TCP1; T-Complex 1; CCT1; D6S230E; Ccta; Chaperonin Containing T-Complex Polypeptide 1 Subunit 1; T-Complex Protein 1 Subunit Alpha; TCP-1-Alpha; CCT-Alpha; T-Complex Protein 1, Alpha Subunit; Tailless Complex Polypeptide 1; T-Complex 1 Protein; CCTA
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human TCP protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    1D5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
  • 基因功能參考文獻：
    1. Chaperonin CCT interferes with fibre assembly by interaction of its CCTzeta and CCTgamma subunits with the A53T central hydrophobic region. This interaction is specific to NAC conformation, as it is produced once soluble alpha-synuclein A53T oligomers form and blocks the reaction before fibres begin to grow. PMID: 28102321
    2. chaperonin-containing TCP-1 complex required for lysosomal functioning and autophagosome degradation PMID: 27929117
    3. Result suggest the positive correlation between purinergic receptor P2X 7 (P2X7R) and T-complex protein 1 (TCP-1) in lymphoma patients. PMID: 26556873
    4. Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1-ETO/RUNX1-RUNX1T1 is facilitated by interaction with the chaperonin TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70). PMID: 26706127
    5. Changes for CRMP2, TCP1epsilon, TPM2 and 14-3-3gamma were confirmed in experimental tumors and in a series of 28 human SI-NETs. PMID: 25224486
    6. A role for the TRiC subunits TCP1 and CCT2, and potentially the entire TRiC complex, in breast cancer. PMID: 25704758
    7. CCT8 might be an oncogene and participate in HCC cell proliferation. PMID: 24862099
    8. identified 6 of the 8 components of the chaperonin-containing TCP-1 (CCT) complex bound to LOX-1 cytoplasmic domain PMID: 24846140
    9. Data suggest that specific molecular mediators involved in glucocerebrosidase maturation and degradation, and abnormal interaction with TCP1 and c-Cbl, could be responsible for phenotypic variation among patients with the same genotypes. PMID: 21098288
    10. the membrane binding domain of CTP:phosphocholine cytidylyltransferase has a role in alveolar type II cells PMID: 19684306
    11. Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1. PMID: 11771755
    12. TRiC chaperonin binds to HIF prolyl hydroxylase PHD3 PMID: 15251459
    13. the strong inhibitory action of PhLP(S) on Gbetagamma signaling is the result of a previously unrecognized mechanism of Gbetagamma-regulation, inhibition of Gbetagamma-folding by interference with TCP-1alpha PMID: 15745879
    14. Data show that Plk1 associates with chaperonin-containing TCP1 complex (CCT) both in vitro and in vivo. PMID: 15923617
    15. The specific and directed rearrangement of the beta-actin structure, seen in the natural beta-actin-TRiC system, is vital for guiding beta-actin to the native state. PMID: 17939680
    16. a paper describing a pathway in which this gene product functions PMID: 1630491

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  • 亞細胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    TCP-1 chaperonin family
  • 數據庫鏈接：

    HGNC: 11655

    OMIM: 186980

    KEGG: hsa:6950

    STRING: 9606.ENSP00000317334

    UniGene: Hs.363137